Understanding Lab Tests for Drug-induced liver injury
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Drug-induced liver injury (DILI) occurs when medications cause damage to liver cells. While there isn't a single blood test that definitively diagnoses drug-induced liver injury, liver enzyme testing is fundamental for detecting liver damage, monitoring the severity of injury, and guiding treatment decisions.
Recommended Test
Aspartate Aminotransferase (AST/SGOT)
AST is a liver enzyme that becomes elevated when liver cells are damaged. This test is crucial for detecting drug-induced liver injury caused by medications such as certain antibiotics, statins, and acetaminophen. Elevated AST levels can indicate ongoing liver damage and help healthcare providers determine whether to adjust or discontinue medication.
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Why Blood Testing is Essential for Drug-induced Liver Injury
Many medications, including common antibiotics, cholesterol-lowering drugs, and over-the-counter pain relievers, can potentially cause liver damage. Blood tests measuring liver enzymes are the primary tool for detecting this damage early, as liver injury often occurs without obvious symptoms until it becomes severe.
When to Consider Testing
Healthcare providers typically recommend liver enzyme testing before starting medications known to potentially affect the liver, and then periodically during treatment. Testing is also important if you experience symptoms like fatigue, nausea, abdominal pain, or yellowing of the skin or eyes while taking medication.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment. If you suspect medication-related liver problems, contact your healthcare provider immediately.
