Dermatitis herpetiformis is an autoimmune skin condition characterized by intensely itchy, blistering rashes that typically appear on the elbows, knees, buttocks, and scalp. It is caused by an immune reaction to gluten that produces tissue transglutaminase (tTG) antibodies, which attack both the intestinal lining and skin. The Celiac Disease Comprehensive Panel is the most important test for diagnosis because it measures tTG antibodies and other celiac-related markers that confirm this autoimmune condition.
90-day money-back guarantee
Lab order in minutes
Save a trip to the doctor
Low prices since 2005
Labs within 2 miles
Dermatitis herpetiformis is caused by an autoimmune reaction to gluten, the protein found in wheat, barley, and rye. When people with this condition consume gluten, their immune system produces tissue transglutaminase (tTG) antibodies that attack not only the small intestine but also create deposits under the skin. These antibody deposits trigger an inflammatory response that results in the characteristic itchy, blistering rash on the elbows, knees, buttocks, and scalp. Nearly 100% of people with dermatitis herpetiformis have underlying celiac disease, even if they experience no digestive symptoms.
The Celiac Disease Comprehensive Panel is the most important test for dermatitis herpetiformis because it detects tissue transglutaminase (tTG) antibodies, endomysial antibodies, and deamidated gliadin peptide antibodies that confirm the autoimmune reaction to gluten. This blood test identifies the elevated antibody levels present in nearly all patients with dermatitis herpetiformis, providing definitive evidence of the underlying celiac disease driving the skin condition. The comprehensive panel not only confirms the diagnosis but also establishes a baseline to monitor your response to a gluten-free diet, which is the primary treatment. While a skin biopsy showing IgA deposits can also diagnose dermatitis herpetiformis, blood testing is less invasive and provides crucial information about the systemic autoimmune process.
You should get tested if you experience intensely itchy, blistering skin rashes that come and go, especially on your elbows, knees, buttocks, or scalp. Testing is particularly important if these skin symptoms appear after eating foods containing wheat, barley, or rye, or if you have a family history of celiac disease or autoimmune conditions. You should also consider testing if you have persistent skin issues that haven't responded to typical eczema or dermatitis treatments, as dermatitis herpetiformis is often misdiagnosed initially. Early diagnosis through blood testing allows you to start a gluten-free diet that can eliminate the rash and prevent long-term complications like intestinal damage and nutritional deficiencies.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
What this means
Your tTG antibody level is elevated, indicating a strong immune response to gluten that suggests celiac disease. This means your body is producing antibodies that attack your small intestine when you consume gluten-containing foods, which can lead to nutrient malabsorption and digestive symptoms.
Recommended actions
Do not start a gluten-free diet yet - continue eating gluten until you consult with a gastroenterologist
Schedule an appointment for an endoscopy with intestinal biopsy to confirm the diagnosis
Keep a food diary tracking symptoms after eating gluten-containing foods
Once diagnosed, work with a registered dietitian specializing in celiac disease to plan a safe gluten-free diet
Not overhyped or overpriced. Just comprehensive blood testing made simple and for everyone.
3303 reviews
Sample results
Your 24/7 Personal Lab Guide
Quick questions:
