Cystic fibrosis is a genetic disorder that primarily affects the lungs, pancreas, liver, kidneys, and intestines by causing thick, sticky mucus buildup. It is caused by mutations in the CFTR gene that controls salt and water movement in and out of cells. The Lysozyme blood test is the most important monitoring test for cystic fibrosis because it measures enzyme levels that reflect chronic inflammation and immune system activity.
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Cystic fibrosis is caused by mutations in the CFTR gene, which is inherited from both parents. This gene controls the movement of salt and water in and out of cells, and when it is defective, thick and sticky mucus builds up in the lungs, pancreas, and other organs. Over time, this mucus traps bacteria and leads to chronic infections, inflammation, and progressive organ damage, particularly in the respiratory and digestive systems.
The Lysozyme blood test is the most important monitoring test for cystic fibrosis because it measures enzyme levels that reflect the chronic inflammation and immune system activity characteristic of CF. While cystic fibrosis itself is diagnosed through genetic testing and sweat chloride tests, the Lysozyme test is valuable for tracking disease progression and monitoring how actively inflammation is affecting your body. Elevated lysozyme levels indicate ongoing inflammatory processes, helping healthcare providers assess disease activity and adjust treatment plans accordingly.
You should get tested if you have a family history of cystic fibrosis or if you are experiencing persistent respiratory infections, chronic cough with thick mucus, difficulty gaining weight, or greasy, foul-smelling stools. Newborn screening programs test all babies for CF, but if you were born before screening was routine or have new symptoms developing, testing is important. Adults who have unexplained chronic sinusitis, bronchitis, or male infertility should also consider getting evaluated for cystic fibrosis, as milder forms can go undiagnosed until later in life.
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What this means
Your lysozyme level is elevated above the optimal range, which indicates increased immune cell turnover. This can occur with inflammation, certain infections, or blood disorders, and warrants follow-up to identify the underlying cause.
Recommended actions
Follow up with your doctor to discuss the elevated result and any symptoms
Focus on anti-inflammatory foods like leafy greens, berries, fatty fish, and turmeric
Ensure adequate rest and stress management to support immune balance
Consider retesting in 4-8 weeks or as recommended by your healthcare provider
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