Understanding Lab Tests for Cushing's Disease
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Cushing's disease is a serious hormonal disorder caused by a pituitary tumor that produces excessive amounts of adrenocorticotropic hormone (ACTH), leading to overproduction of cortisol by the adrenal glands. Accurate diagnosis requires specific blood tests to measure hormone levels.
Recommended Test
Adrenocorticotropic Hormone (ACTH)
This test measures ACTH levels in the blood, which is crucial for diagnosing Cushing's disease. When a pituitary tumor produces excess ACTH, it stimulates the adrenal glands to overproduce cortisol. Elevated ACTH levels help confirm that the excess cortisol is due to pituitary-driven disease rather than other causes, making this test fundamental for accurate diagnosis and treatment planning.
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Diagnosing Cushing's Disease
Because the symptoms of Cushing's disease can be subtle initially and may overlap with other conditions, laboratory testing is essential for confirming the diagnosis. Blood tests that measure specific hormones help differentiate Cushing's disease from other causes of excess cortisol and guide appropriate treatment decisions.
Understanding Your Results
ACTH testing helps healthcare providers determine the source of excess cortisol production. High ACTH levels typically indicate that a pituitary tumor is driving the overproduction of cortisol, confirming a diagnosis of Cushing's disease. This information is critical for determining the most appropriate treatment approach.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment. Additional imaging studies may be recommended alongside blood testing for comprehensive evaluation.
