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Congenital CMV infection occurs when cytomegalovirus is transmitted from a pregnant woman to her developing fetus during pregnancy. It is caused by the cytomegalovirus entering the bloodstream of a mother who has never been infected before, then crossing the placenta to infect the baby. The Cytomegalovirus (CMV) Antibodies, IgM, Quantitative test is the most important test for diagnosing congenital CMV infection in newborns.
Congenital CMV infection is caused by the cytomegalovirus (CMV) passing from a pregnant woman to her unborn baby through the placenta. This typically happens when a woman becomes infected with CMV for the first time during pregnancy, as the virus enters her bloodstream and crosses the placental barrier. The virus can also be transmitted if a previously infected mother experiences a reactivation of dormant CMV or gets infected with a different strain during pregnancy, though primary infections pose the highest risk to the developing fetus.
The Cytomegalovirus (CMV) Antibodies, IgM, Quantitative test is the most important test for congenital CMV infection because it detects the presence and amount of CMV IgM antibodies in an infant's blood. These IgM antibodies are the immune system's first response to a CMV infection and indicate a recent or active infection that was transmitted during pregnancy. The test provides definitive evidence of congenital CMV infection and allows healthcare providers to determine the severity of the infection and begin appropriate monitoring and treatment to minimize potential complications like hearing loss, vision problems, and developmental delays.
You should get your infant tested for congenital CMV infection if you had a confirmed or suspected CMV infection during pregnancy, especially during the first trimester when transmission risk is highest. Testing is also recommended if your newborn shows symptoms such as jaundice, enlarged liver or spleen, low birth weight, small head size, rash at birth, or seizures. Early testing within the first three weeks of life is essential because it allows for prompt intervention and monitoring to address potential complications and improve long-term outcomes for your child.
What this means
Your CMV IgM antibody test came back negative, meaning no IgM antibodies were detected in your blood. This suggests you do not have a recent or current CMV infection, which is a normal and healthy result.
Recommended actions
If you're pregnant or planning pregnancy, discuss preventive measures with your doctor to avoid CMV exposure
Practice good hygiene including frequent handwashing, especially if you work with young children
If symptoms develop later or you have known exposure, consider retesting in 2-4 weeks
Maintain a healthy immune system through balanced nutrition, adequate sleep, and stress management
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