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Confirmed hepatitis infection is inflammation of the liver caused by viral infection. It is caused by one of five hepatitis viruses: hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), or hepatitis E virus (HEV). The Hepatitis Panel Acute with Reflex Confirmation is the most important test for diagnosis because it identifies which specific virus is present and confirms active infection.
Confirmed hepatitis infection is caused by one of five hepatitis viruses: hepatitis A virus (HAV), hepatitis B virus (HBV), hepatitis C virus (HCV), hepatitis D virus (HDV), or hepatitis E virus (HEV). Each virus has different transmission routesâHAV and HEV spread through contaminated food or water, while HBV, HCV, and HDV spread through blood contact, sexual transmission, or from mother to baby during birth. Once the virus enters your body, it attacks liver cells and triggers inflammation that can range from mild to severe, potentially leading to chronic liver disease or liver failure if left untreated.
The Hepatitis Panel Acute with Reflex Confirmation is the most important test for confirmed hepatitis infection because it screens for all five hepatitis viruses (A, B, C, D, and E) and confirms which specific virus is causing your infection. This comprehensive panel detects viral antibodies and antigens in your blood that indicate active infection, helping your doctor determine whether you have acute or chronic hepatitis. The test identifies hepatitis A IgM antibodies, hepatitis B surface antigen and core antibodies, hepatitis C antibodies with reflex RNA testing, and markers for hepatitis D and E when indicated. Knowing the exact virus type is essential because each hepatitis virus requires different treatment approaches and has different long-term health implications.
You should get tested if you experience symptoms like persistent fatigue, yellowing of your skin or eyes (jaundice), dark urine, pale stools, abdominal pain in the upper right side, nausea, vomiting, or unexplained fever. Testing is also critical if you have been exposed to someone with hepatitis, received a blood transfusion before 1992, share needles, have multiple sexual partners, traveled to areas with poor sanitation, work in healthcare, or have abnormal liver enzyme results from routine blood work. Early detection through blood testing allows for prompt treatment and helps prevent liver damage and transmission to others.
What this means
Your test came back negative, meaning no Hepatitis B surface antigen was detected in your blood. This is the expected and healthy result, indicating you do not have an active Hepatitis B infection.
Recommended actions
Consider Hepatitis B vaccination if not already vaccinated for long-term protection
Practice safe sex and avoid sharing needles or personal care items
If you have ongoing liver symptoms, discuss additional liver function tests with your doctor
Retest if you have potential exposure or work in high-risk environments
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