Understanding Lab Tests for Common Variable Immunodeficiency
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Common Variable Immunodeficiency (CVID) is a primary immunodeficiency disorder characterized by significantly reduced levels of immunoglobulins (antibodies) in the blood. This condition leads to recurrent infections and requires specific blood tests to measure antibody levels for accurate diagnosis.
Top Recommended Test
IgG, IgA, Indirect Immunofluorescence
This comprehensive test measures multiple immunoglobulin levels, including IgG and IgA, which are both typically reduced in Common Variable Immunodeficiency. Low IgG levels are particularly significant as they lead to frequent bacterial infections due to a severely weakened immune response, making this test essential for confirming the diagnosis.
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Diagnosing Common Variable Immunodeficiency
CVID diagnosis relies on laboratory testing to measure specific immunoglobulin levels in the blood. These tests directly detect the low antibody levels that define this condition, distinguishing it from other causes of recurrent infections and confirming the immune system deficiency.
Other Relevant Tests
IgA
This test measures Immunoglobulin A levels in the blood, which are characteristically low in Common Variable Immunodeficiency. IgA deficiency is one of the key markers used to diagnose this group of disorders, as reduced IgA levels contribute to increased susceptibility to infections, particularly in mucosal areas.
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Understanding Your Results
Significantly reduced levels of IgG, IgA, and sometimes IgM immunoglobulins are the hallmark findings in CVID. These low antibody levels explain the increased susceptibility to bacterial and viral infections that patients with this condition experience. Early diagnosis through proper testing is crucial for implementing appropriate treatment strategies.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment of immunodeficiency disorders.
