Question 1

What is Common Variable Immunodeficiency?

Accepted Answer

Common Variable Immunodeficiency (CVID) is a primary immune disorder characterized by significantly reduced levels of immunoglobulins (antibodies) in the blood. It is caused by genetic defects that impair B cells from producing adequate amounts of IgG, IgA, and sometimes IgM antibodies. The IgG, IgA, Indirect Immunofluorescence test is the most important test for diagnosis because it measures multiple immunoglobulin levels simultaneously to confirm antibody deficiency.

Question 2

What causes Common Variable Immunodeficiency?

Accepted Answer

Common Variable Immunodeficiency is caused by genetic mutations that affect B cells, preventing them from maturing properly and producing adequate antibodies. While the exact genetic defects vary between individuals, these mutations impair the immune system's ability to make immunoglobulins like IgG, IgA, and IgM. Without sufficient antibodies, your body cannot effectively fight off bacteria, viruses, and other pathogens, leading to recurrent infections throughout life.

Question 3

What is the best test for Common Variable Immunodeficiency?

Accepted Answer

The IgG, IgA, Indirect Immunofluorescence test is the most important test for Common Variable Immunodeficiency because it measures multiple critical antibody levels in a single comprehensive panel. This test detects significantly reduced levels of IgG and IgA immunoglobulins, which are the hallmark findings needed to confirm CVID diagnosis. The IgA test can also be used as a supplementary measure to specifically assess Immunoglobulin A deficiency, which contributes to increased susceptibility to respiratory and gastrointestinal infections. Together, these tests provide the essential antibody measurements that distinguish CVID from other causes of recurrent infections.

Question 4

When should I get tested for Common Variable Immunodeficiency?

Accepted Answer

You should get tested if you experience frequent bacterial infections like pneumonia, bronchitis, or sinus infections that keep coming back despite treatment. Testing is also important if you have chronic diarrhea, ear infections that won't resolve, or unusual infections that healthy people rarely get. Adults who suddenly develop recurrent infections in their 20s or 30s, or children with persistent infections affecting the lungs, ears, or sinuses should consider immunoglobulin testing to identify potential antibody deficiencies early.

Question 5

What are the symptoms of Common Variable Immunodeficiency?

Accepted Answer

The primary symptoms of CVID include recurrent bacterial infections affecting the respiratory system, such as chronic bronchitis, pneumonia, and persistent sinus infections. You might also experience frequent ear infections, chronic diarrhea with weight loss, and autoimmune complications like arthritis or blood disorders. Some people develop enlarged lymph nodes or spleen, and may notice they take much longer to recover from common illnesses compared to others. These symptoms typically begin in early adulthood but can appear in childhood or later in life.

Question 6

Who is at risk for Common Variable Immunodeficiency?

Accepted Answer

CVID can affect anyone, though it most commonly appears in adults between ages 20 and 40, or in children between ages 1 and 5. People with a family history of immunodeficiency disorders have a higher risk, as genetic factors play a significant role. Both men and women are equally affected by this condition. While most cases occur sporadically without clear inheritance patterns, having close relatives with immune disorders or frequent infections increases your likelihood of developing CVID.

Question 7

What happens if Common Variable Immunodeficiency is left untreated?

Accepted Answer

Untreated CVID leads to progressively worsening infections that can cause permanent lung damage, a condition called bronchiectasis, where airways become scarred and widened. You face increased risk of developing autoimmune diseases, chronic gastrointestinal problems with malabsorption, and significantly higher chances of certain cancers, particularly lymphoma. Repeated infections can damage organs over time, reduce quality of life dramatically, and potentially become life-threatening. Early diagnosis and treatment with immunoglobulin replacement therapy can prevent these serious complications and help you maintain a much more normal, healthy life.

Question 8

Can Common Variable Immunodeficiency be diagnosed with a blood test?

Accepted Answer

Yes, Common Variable Immunodeficiency is definitively diagnosed through blood tests that measure immunoglobulin levels. The blood work checks your IgG, IgA, and IgM antibody concentrations, and significantly reduced levels of these antibodies confirm the diagnosis. Additional blood tests may evaluate your B cell function and vaccine response to understand how well your immune system can produce antibodies. These laboratory tests are essential and sufficient for diagnosing CVID without requiring invasive procedures.

Question 9

How is Common Variable Immunodeficiency treated?

Accepted Answer

CVID is primarily treated with regular immunoglobulin replacement therapy, where you receive infusions of antibodies either intravenously every 3-4 weeks or subcutaneously more frequently at home. This replacement therapy provides the missing antibodies your body cannot produce, significantly reducing infection frequency. Your doctor will also prescribe antibiotics promptly when infections occur, and may recommend preventive antibiotics for chronic issues. Some patients need treatments for associated autoimmune conditions or gastrointestinal complications, and regular monitoring helps adjust therapy to keep you as healthy as possible.

Question 10

How can I prevent complications from Common Variable Immunodeficiency?

Accepted Answer

While you cannot prevent CVID itself, you can prevent complications by maintaining consistent immunoglobulin replacement therapy as prescribed and never skipping treatments. Practice excellent hygiene, including frequent handwashing and avoiding people who are sick when possible. Stay up to date with recommended vaccines, though live vaccines should be avoided. Regular follow-up appointments with your immunologist help catch problems early, and promptly treating any new infections prevents them from becoming serious. Maintaining good nutrition, adequate sleep, and avoiding smoking protects your lungs from additional damage.

Question 11

What can I do at home to support my immune system with Common Variable Immunodeficiency?

Accepted Answer

At home, focus on maintaining a healthy lifestyle with balanced nutrition rich in fruits, vegetables, and lean proteins to support overall health despite antibody deficiency. Stay well-hydrated, get adequate sleep of 7-9 hours nightly, and manage stress through relaxation techniques, as stress can impact immune function. Keep your living space clean and avoid exposure to mold or environmental irritants that could harm your lungs. While these measures cannot replace medical treatment, they complement immunoglobulin therapy and help minimize infection risk. Always consult your healthcare provider before trying supplements or alternative remedies, as some may interfere with your treatment.

Question 12

How’s this work?

Accepted Answer

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Question 13

How do I know which test to get?

Accepted Answer

In the test options, find the test you want.
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Question 14

When will my lab results be available?

Accepted Answer

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know.
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Question 15

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Accepted Answer

Absolutely! We totally understand that errors can happen. No worries, we're here to help you.
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Question 16

Do you accept health insurance?

Accepted Answer

Only HSA & FSA is accepted.
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Question 17

Can I cancel my order?

Accepted Answer

Yes.
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Question 18

How can I find a lab location near me?

Accepted Answer

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Common Variable Immunodeficiency Blood Test

What is Common Variable Immunodeficiency?

What causes Common Variable Immunodeficiency?

What is the best test for Common Variable Immunodeficiency?

When should I get tested for Common Variable Immunodeficiency?

References

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