Sample results
CMV mononucleosis is a viral infection that causes fatigue, fever, sore throat, and swollen lymph nodes similar to infectious mononucleosis. It is caused by cytomegalovirus (CMV), a common herpes virus that spreads through bodily fluids like saliva, blood, and urine. The Cytomegalovirus (CMV) Antibodies, IgM, Quantitative test is the most important test for diagnosis because it detects active or recent CMV infection.
CMV mononucleosis is caused by cytomegalovirus (CMV), a member of the herpes virus family. The virus spreads through close contact with infected bodily fluids including saliva, blood, urine, semen, breast milk, and tears. You can contract CMV through kissing, sharing utensils or drinks, sexual contact, blood transfusions, or organ transplants from an infected person. Once infected, the virus remains dormant in your body for life and can reactivate when your immune system is weakened.
The Cytomegalovirus (CMV) Antibodies, IgM, Quantitative test is the most important test for CMV mononucleosis because it detects IgM antibodies that appear early during active or recent CMV infection. This test measures specific antibody levels in your blood and distinguishes CMV mononucleosis from other causes of mono-like symptoms, particularly Epstein-Barr virus (EBV) infection. High levels of CMV IgM antibodies combined with typical mononucleosis symptoms confirm the diagnosis and help your healthcare provider determine the most appropriate treatment approach for your specific infection.
You should get tested if you have prolonged fatigue, fever, sore throat, and swollen lymph nodes that last more than a week, especially if you tested negative for Epstein-Barr virus but still have mono-like symptoms. Testing is also important if you are pregnant and develop these symptoms, as CMV can affect your baby, or if you have a weakened immune system from HIV, organ transplant, or chemotherapy. Get tested immediately if you experience severe fatigue that interferes with daily activities, persistent fever above 101°F, or swollen lymph nodes that do not improve after two weeks.
What this means
Your CMV IgM antibody test came back negative, meaning no IgM antibodies were detected in your blood. This suggests you do not have a recent or current CMV infection, which is a normal and healthy result.
Recommended actions
If you're pregnant or planning pregnancy, discuss preventive measures with your doctor to avoid CMV exposure
Practice good hygiene including frequent handwashing, especially if you work with young children
If symptoms develop later or you have known exposure, consider retesting in 2-4 weeks
Maintain a healthy immune system through balanced nutrition, adequate sleep, and stress management
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Sample results
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