Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Chronic viral infections are long-term infections caused by various viruses that persist in the body for months or years. These infections typically require specific viral tests or molecular diagnostics for definitive identification. However, blood testing is fundamental for monitoring the immune system's response and assessing the body's ability to fight these persistent infections.
This test measures the ratio between CD4 helper T cells and CD8 cytotoxic T cells, providing crucial insight into immune system balance. In chronic viral infections like hepatitis or cytomegalovirus, the CD4:CD8 ratio often becomes decreased due to increased CD8 cell proliferation as the immune system actively responds to fight the persistent viral infection. This information helps assess immune function and monitor disease progression.
Chronic viral infections can significantly impact immune function over time. Monitoring immune cell populations helps healthcare providers understand how well your body is responding to the infection, guide treatment decisions, and assess the need for additional interventions or therapies.
Changes in the CD4:CD8 ratio can indicate how your immune system is responding to chronic viral infection. A decreased ratio may suggest active immune response, while monitoring trends over time helps healthcare providers adjust treatment strategies and assess recovery progress.
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.