Understanding Lab Tests for Chronic Urticaria
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Chronic urticaria, also known as chronic hives, is a condition characterized by the recurring development of raised, itchy welts (hives) on the skin that persist for six weeks or longer. While the diagnosis is primarily made through clinical examination and medical history, blood tests play a crucial role in identifying potential triggers and understanding the underlying mechanisms causing the condition.
Top Recommended Test
Histamine Release (Chronic Urticaria)
This specialized test directly measures histamine release from mast cells, which is the primary mechanism behind chronic urticaria. When mast cells release histamine, it causes the characteristic inflammation, swelling, and hive formation seen in this condition. This test helps confirm the histamine-mediated nature of your symptoms.
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Why Blood Testing is Important for Chronic Urticaria
Although there isn't a single blood test that definitively diagnoses chronic urticaria itself, laboratory testing is fundamental for identifying specific allergens that may be triggering the hives, measuring inflammatory markers, and assessing the body's histamine response. This information helps healthcare providers develop targeted treatment plans and identify avoidable triggers.
Other Relevant Tests
Cat Epithelium/Dander (e1) IgG
This test measures IgG antibodies to cat dander, which can help identify if exposure to cats is triggering your chronic urticaria. Elevated levels of these antibodies may indicate that cat allergens are contributing to your recurring hives and could be an important trigger to avoid.
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Histamine, Plasma
This test measures the level of histamine circulating in your blood plasma. People with chronic urticaria often have elevated plasma histamine levels, which correlates with the severity of their hives, itching, and skin inflammation. This test helps assess the overall histamine activity in your system.
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Understanding Your Results
Test results should always be interpreted by a healthcare provider in the context of your symptoms and medical history. Identifying specific triggers through allergy testing can help you avoid substances that worsen your condition, while histamine measurements can guide treatment decisions and monitor your response to therapy.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment of chronic urticaria.
