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Chronic pancreatitis is a long-term inflammatory condition that gradually destroys pancreatic tissue and impairs digestive function. It is caused by repeated episodes of pancreatic inflammation, most commonly from alcohol abuse, genetic mutations, or blocked pancreatic ducts. The Lipase Serum test is the most important test for monitoring chronic pancreatitis because it detects elevated pancreatic enzyme levels during inflammatory episodes.
Chronic pancreatitis is caused by repeated episodes of pancreatic inflammation that damage the organ over time. Alcohol abuse is the leading cause, accounting for 70-80% of cases, while other triggers include genetic mutations like CFTR and PRSS1 genes, autoimmune diseases, chronic blockage of pancreatic ducts, high triglyceride levels, and prolonged use of certain medications. The ongoing inflammation creates scar tissue that replaces healthy pancreatic cells, progressively destroying the organ's ability to produce digestive enzymes and insulin.
The Lipase Serum test is the most important blood test for chronic pancreatitis because it detects elevated levels of this pancreatic enzyme during active inflammatory episodes. Lipase remains elevated longer than other enzymes, making it more sensitive for identifying flare-ups. The Amylase Serum test provides additional monitoring of pancreatic function, though levels may become normal or low as the disease progresses and enzyme-producing cells are destroyed. The Carbohydrate Antigen CA 19-9 test helps monitor chronic inflammation and can distinguish inflammatory conditions from other pancreatic disorders. The Pancreatic Exocrine Cell Antibody test identifies autoimmune involvement when antibodies against pancreatic cells are present.
You should get tested if you experience persistent upper abdominal pain that radiates to your back, unexplained weight loss despite eating normally, oily or greasy stools that float and have a foul odor, frequent nausea and vomiting after meals, or yellowing of your skin and eyes. Testing is especially important if you have a history of heavy alcohol use, recurrent acute pancreatitis episodes, or a family history of pancreatic disease. Early detection helps prevent further pancreatic damage and allows for better management of symptoms and complications.
What this means
Your lipase level is elevated above the normal range, which may indicate inflammation or stress on your pancreas. This can be associated with pancreatitis, gallstones, or other digestive issues. While moderately elevated levels require attention, they don't always indicate a severe condition.
Recommended actions
Avoid alcohol completely and limit fatty, fried, and processed foods
Eat smaller, more frequent meals with lean proteins and vegetables
Stay well-hydrated with plenty of water throughout the day
Follow up with a gastroenterologist to determine the underlying cause
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