Question 1

What is Chronic Non-Spherocytic Hemolytic Anemia (CNSHA)?

Accepted Answer

Chronic Non-Spherocytic Hemolytic Anemia (CNSHA) is a rare inherited blood disorder where red blood cells break down prematurely due to enzyme deficiencies. It is caused by severe glucose-6-phosphate dehydrogenase (G6PD) deficiency, which makes red blood cells fragile and unable to survive normally. The Glucose-6-Phosphate Dehydrogenase Quantitative test is the most important test for diagnosing CNSHA because it measures the exact level of G6PD enzyme activity in red blood cells.

Question 2

What causes Chronic Non-Spherocytic Hemolytic Anemia?

Accepted Answer

CNSHA is caused by inherited enzyme deficiencies in red blood cells, most commonly severe glucose-6-phosphate dehydrogenase (G6PD) deficiency. The G6PD enzyme protects red blood cells from oxidative damage, and when it is severely deficient, red blood cells become fragile and break down prematurely in the bloodstream. Unlike other types of hemolytic anemia, the red blood cells maintain their normal disc shape but still die early, leading to chronic anemia and ongoing symptoms throughout life.

Question 3

What is the best test for Chronic Non-Spherocytic Hemolytic Anemia?

Accepted Answer

The Glucose-6-Phosphate Dehydrogenase Quantitative test is the most important test for CNSHA because it directly measures the amount of G6PD enzyme activity in your red blood cells. This test identifies severe enzyme deficiency that causes the chronic breakdown of red blood cells characteristic of CNSHA. The quantitative measurement is essential because it determines the severity of the deficiency and helps healthcare providers understand how significantly your red blood cells are affected. By measuring exact enzyme levels rather than just detecting presence or absence, this test provides the critical information needed to confirm a CNSHA diagnosis and guide treatment strategies.

Question 4

When should I get tested for Chronic Non-Spherocytic Hemolytic Anemia?

Accepted Answer

You should get tested if you experience ongoing fatigue, pale skin, jaundice (yellowing of skin or eyes), dark urine, or an enlarged spleen without an obvious cause. Testing is especially important if you have a family history of anemia or blood disorders, if you come from Mediterranean, African, or Asian ancestry where G6PD deficiency is more common, or if you have chronic anemia that does not respond to typical treatments like iron supplementation. Early diagnosis helps prevent complications from chronic anemia and allows you to avoid triggers that might worsen red blood cell breakdown.

Question 5

What are the symptoms of Chronic Non-Spherocytic Hemolytic Anemia?

Accepted Answer

CNSHA causes persistent fatigue, weakness, and pale skin due to chronic anemia from ongoing red blood cell breakdown. You might notice jaundice (yellowing of the eyes and skin), dark-colored urine from excess bilirubin, and shortness of breath during normal activities. Some people develop an enlarged spleen as it works overtime to remove damaged red blood cells, which can cause discomfort in the upper left abdomen. Unlike acute hemolytic episodes, CNSHA symptoms are continuous and present throughout life, though they may worsen during infections or exposure to certain medications or foods.

Question 6

Who is at risk for Chronic Non-Spherocytic Hemolytic Anemia?

Accepted Answer

CNSHA primarily affects people who inherit severe forms of enzyme deficiency genes, particularly G6PD deficiency, which is more common in people of Mediterranean, African, Middle Eastern, and Asian descent. Males are more frequently affected because the G6PD gene is located on the X chromosome, making males more likely to express severe deficiency if they inherit one abnormal gene. Having family members with unexplained anemia, a history of chronic jaundice, or relatives who experienced severe reactions to certain medications or fava beans increases your risk of carrying the genetic mutation that causes CNSHA.

Question 7

What happens if Chronic Non-Spherocytic Hemolytic Anemia is left untreated?

Accepted Answer

Untreated CNSHA leads to ongoing complications from chronic anemia, including severe fatigue that affects daily functioning, poor growth and development in children, and increased risk of infections due to an overworked immune system. The continuous breakdown of red blood cells causes excess bilirubin, which can lead to gallstones at a young age and potential liver problems over time. The spleen becomes progressively enlarged from constantly filtering damaged red blood cells, which can cause pain and further complications. Without proper diagnosis and management, severe anemia can strain the heart and other organs that struggle to function with reduced oxygen delivery.

Question 8

Can Chronic Non-Spherocytic Hemolytic Anemia be diagnosed with a blood test?

Accepted Answer

Yes, CNSHA is diagnosed primarily through blood tests that measure enzyme levels in red blood cells. The Glucose-6-Phosphate Dehydrogenase Quantitative test directly measures G6PD enzyme activity and is the definitive test for diagnosing the most common cause of CNSHA. Additional blood tests like a complete blood count (CBC) reveal chronic anemia, and a reticulocyte count shows if your body is trying to make new red blood cells to replace those being destroyed. A peripheral blood smear can show that red blood cells maintain their normal disc shape rather than becoming spherical, which is characteristic of CNSHA and helps distinguish it from other types of hemolytic anemia.

Question 9

How is Chronic Non-Spherocytic Hemolytic Anemia treated?

Accepted Answer

CNSHA treatment focuses on avoiding triggers that worsen red blood cell breakdown and managing chronic anemia symptoms. You must avoid certain medications (like sulfa drugs and antimalarials), foods (especially fava beans for G6PD deficiency), and substances that cause oxidative stress to red blood cells. Folic acid supplementation helps your body produce new red blood cells more effectively, and in severe cases, blood transfusions may be necessary during periods of worsening anemia. Some people require spleen removal (splenectomy) if the spleen becomes severely enlarged or if anemia is particularly severe, though this decision is made carefully as the spleen plays an important role in immune function.

Question 10

How can I prevent Chronic Non-Spherocytic Hemolytic Anemia?

Accepted Answer

CNSHA itself cannot be prevented because it is an inherited genetic condition, but you can prevent complications and worsening of symptoms by avoiding known triggers. If you have been diagnosed with G6PD deficiency, strictly avoid fava beans, certain medications (including specific antibiotics, antimalarials, and pain relievers), mothballs (naphthalene), and henna-based products that can trigger red blood cell breakdown. Genetic counseling before having children can help you understand the risk of passing the condition to your offspring. Staying current with vaccinations helps prevent infections that might worsen anemia, and maintaining regular follow-up with healthcare providers allows for monitoring and early intervention if complications develop.

Question 11

What can I do at home for Chronic Non-Spherocytic Hemolytic Anemia?

Accepted Answer

Managing CNSHA at home involves maintaining a list of medications and foods to avoid, which you should share with all healthcare providers and keep readily accessible. Eat a nutrient-rich diet with adequate folic acid from leafy greens, beans, and fortified grains to support red blood cell production, and stay well-hydrated to help your kidneys process waste products from red blood cell breakdown. Get adequate rest when you feel fatigued, and pace activities to conserve energy during periods of worsening anemia. Monitor yourself for signs of increasing jaundice, darker urine, or new symptoms, and seek medical attention promptly if you develop infections or are exposed to potential triggers, as early intervention can prevent severe hemolytic episodes.

Question 12

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Accepted Answer

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Question 13

How do I know which test to get?

Accepted Answer

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Question 14

When will my lab results be available?

Accepted Answer

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know.
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Question 15

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Accepted Answer

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Question 16

Do you accept health insurance?

Accepted Answer

Only HSA & FSA is accepted.
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Question 17

Can I cancel my order?

Accepted Answer

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Question 18

How can I find a lab location near me?

Accepted Answer

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Chronic Hemolytic Anemia Blood Test

What is Chronic Non-Spherocytic Hemolytic Anemia (CNSHA)?

What causes Chronic Non-Spherocytic Hemolytic Anemia?

What is the best test for Chronic Non-Spherocytic Hemolytic Anemia?

When should I get tested for Chronic Non-Spherocytic Hemolytic Anemia?

References

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