Understanding Lab Tests for Chronic Non-Spherocytic Hemolytic Anemia (CNSHA)
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Chronic Non-Spherocytic Hemolytic Anemia (CNSHA) is a rare inherited blood disorder characterized by the premature destruction of red blood cells due to enzyme deficiencies. This condition leads to chronic anemia and requires specific blood testing to identify the underlying enzymatic cause.
Recommended Test
Glucose-6-Phosphate Dehydrogenase Quantitative
This test measures the level of G6PD enzyme in red blood cells. CNSHA is most commonly associated with severe G6PD deficiency, where insufficient enzyme activity leads to premature breakdown of red blood cells and chronic hemolytic anemia. A quantitative measurement helps determine the severity of the deficiency and confirms the diagnosis.
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What is CNSHA?
CNSHA occurs when red blood cells have defective enzymes that are essential for their normal function and survival. The most common cause is severe glucose-6-phosphate dehydrogenase (G6PD) deficiency, which makes red blood cells fragile and prone to breaking down prematurely. Unlike other types of hemolytic anemia, the red blood cells in CNSHA maintain their normal disc shape rather than becoming spherical.
Diagnosing CNSHA with Blood Testing
Accurate diagnosis of CNSHA requires specialized blood testing to measure specific enzyme levels in red blood cells. These tests can identify enzyme deficiencies that cause the chronic hemolysis and help healthcare providers develop appropriate treatment strategies.
Understanding Your Results
Severely reduced G6PD enzyme levels indicate a deficiency that can cause CNSHA. The quantitative nature of this test allows healthcare providers to assess the degree of deficiency and its potential impact on red blood cell survival. Early diagnosis is important for managing symptoms and preventing complications from chronic anemia.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for proper diagnosis, interpretation of test results, and treatment of CNSHA.
