Chronic inflammatory diseases are conditions where the immune system causes persistent inflammation affecting multiple body systems, including rheumatoid arthritis, lupus, Crohn's disease, and inflammatory bowel disease. They are caused by an overactive immune response that attacks healthy tissues, producing abnormal levels of inflammatory proteins and immune cells in the bloodstream. The Protein Electrophoresis with Total Protein test is the most important test for diagnosis because it detects characteristic protein pattern changes that indicate active inflammation.
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Chronic inflammatory diseases are caused by an overactive immune system that mistakenly attacks healthy tissues in your body. In conditions like rheumatoid arthritis, immune cells target joint tissue, while in lupus, antibodies attack multiple organs including skin, kidneys, and blood vessels. Crohn's disease and inflammatory bowel disease occur when immune cells attack the digestive tract lining. The exact trigger varies, but genetics, environmental factors, infections, and gut bacteria imbalances can all activate this abnormal immune response that leads to persistent inflammation.
The Protein, Total and Protein Electrophoresis test is the most important test for chronic inflammatory diseases because it detects characteristic changes in protein patterns that indicate active inflammation. This test measures albumin, globulins, and other protein fractions that become abnormal when conditions like rheumatoid arthritis or lupus are present. The Protein Electrophoresis with Total Protein and Reflex to IFE provides even more comprehensive analysis by automatically performing immunofixation if abnormalities are detected. For a complete assessment, the Immune Cell Function test is essential as it directly measures how your immune cells are behaving, revealing the overactive immune response that drives these conditions.
You should get tested if you experience persistent joint pain and stiffness that lasts more than six weeks, especially if it's worse in the morning. Other warning signs include unexplained fatigue that doesn't improve with rest, recurring fevers without infection, skin rashes that come and go, or digestive problems like chronic diarrhea and abdominal pain. If you have a family history of autoimmune conditions like rheumatoid arthritis or lupus, testing is particularly important when symptoms appear. Early detection through blood tests can help you start treatment before permanent damage occurs to your joints, organs, or digestive system.
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What this means
Your total protein level is slightly below the optimal range, which may indicate inadequate protein intake, absorption issues, or increased protein loss. Low protein levels can contribute to fatigue, weakness, and reduced immune function over time.
Recommended actions
Increase protein-rich foods like lean meats, fish, eggs, legumes, and dairy
Ensure adequate calorie intake to prevent protein being used for energy
Consider digestive health if you experience bloating or GI symptoms
Retest in 2-3 months after dietary adjustments to monitor improvement
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