Chronic inflammatory disease is a group of conditions characterized by persistent inflammation affecting multiple organ systems including rheumatoid arthritis, lupus, and inflammatory bowel disease. These conditions are caused by immune system overactivity where the body attacks its own tissues, producing elevated levels of acute phase reactants and inflammatory proteins. The Protein, Total and Protein Electrophoresis test is the most important test for diagnosing chronic inflammatory disease because it reveals specific protein patterns and inflammatory markers elevated during active inflammation.
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Chronic inflammatory disease is caused by immune system dysfunction where your body mistakenly attacks its own healthy tissues and organs. This autoimmune response triggers the release of inflammatory cytokines like interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-alpha), and C-reactive protein (CRP), which sustain ongoing inflammation. Environmental factors, genetic predisposition, infections, and lifestyle factors like stress and poor diet can all trigger or worsen this immune system overactivity, leading to conditions such as rheumatoid arthritis, lupus, inflammatory bowel disease, and psoriasis.
The Protein, Total and Protein Electrophoresis test is the most important test for chronic inflammatory disease because it analyzes different protein fractions in your blood and reveals elevated acute phase reactants that rise during inflammation. This test shows specific protein patterns including increased alpha-1 and alpha-2 globulins, which are hallmark signs of active inflammation. For a more comprehensive evaluation, the Protein Electrophoresis and Kappa/Lambda Light Chains test provides advanced protein analysis that detects elevated beta-2 globulin levels and abnormal light chain patterns associated with chronic inflammation. The Rubella Immune Status test can also reveal immune system abnormalities linked to autoimmune inflammatory conditions like rheumatoid arthritis and lupus.
You should get tested if you experience persistent joint pain, stiffness, or swelling that lasts more than six weeks, unexplained fatigue that interferes with daily activities, recurring fevers without clear infection, or digestive issues like chronic diarrhea and abdominal pain. Testing is also important if you notice skin rashes or changes, unexplained weight loss, or if you have a family history of autoimmune conditions like rheumatoid arthritis, lupus, or inflammatory bowel disease. Early detection through blood testing helps identify inflammation markers before irreversible organ damage occurs and allows for timely treatment to manage symptoms and prevent progression.
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What this means
Your total protein level is slightly below the optimal range, which may indicate inadequate protein intake, absorption issues, or increased protein loss. Low protein levels can contribute to fatigue, weakness, and reduced immune function over time.
Recommended actions
Increase protein-rich foods like lean meats, fish, eggs, legumes, and dairy
Ensure adequate calorie intake to prevent protein being used for energy
Consider digestive health if you experience bloating or GI symptoms
Retest in 2-3 months after dietary adjustments to monitor improvement
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