Chronic infections are persistent infections lasting months or years caused by bacteria, viruses, fungi, or parasites that evade the immune system. These infections occur when pathogens like Mycobacterium tuberculosis, Epstein-Barr virus, Hepatitis B or C viruses, or Candida species overwhelm or escape initial immune responses. The IgG and IgA Indirect Immunofluorescence test is the most important screening test for chronic infections because it measures elevated antibody levels indicating ongoing immune system activation.
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Chronic infections are caused by pathogens that your immune system cannot completely eliminate, including bacteria like Mycobacterium tuberculosis and Helicobacter pylori, viruses such as Epstein-Barr virus, Hepatitis B and C, HIV, and herpes simplex virus, as well as fungi like Candida species and parasites. These organisms develop strategies to hide from or suppress your immune system, allowing them to persist in your body for extended periods. Risk factors that enable chronic infections include weakened immunity from conditions like diabetes or HIV, incomplete antibiotic treatment, biofilm formation by bacteria, and genetic factors affecting immune function.
The IgG and IgA Indirect Immunofluorescence test is the most important screening test for chronic infections because it measures your immune system's antibody response to persistent pathogens. Elevated IgG levels indicate your body is actively producing long-term antibodies to fight ongoing infections, while IgA levels reflect mucosal immunity against infections in your respiratory and digestive tracts. This test provides a broad assessment of immune activation and helps determine if you need additional pathogen-specific testing, such as viral load tests for Hepatitis C, tuberculosis screening, or bacterial cultures to identify the exact infectious agent causing your symptoms.
You should get tested if you experience persistent fatigue lasting more than three months, recurrent fevers without obvious cause, night sweats, unexplained weight loss, or symptoms that improve temporarily with antibiotics but return after treatment ends. Testing is also important if you have a weakened immune system from conditions like diabetes, HIV, or cancer treatment, or if you have been diagnosed with an acute infection that has not fully resolved after standard treatment. Early detection through blood testing helps identify the underlying cause and prevents complications from untreated chronic infections.
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What this means
Your test came back negative, meaning no anti-epithelial cell surface antibodies were detected in your blood. This is the expected and healthy result, suggesting no active autoimmune blistering disease affecting the connections between skin cells.
Recommended actions
Continue monitoring any skin symptoms and report new blistering to your doctor
Maintain good skin care practices and protect skin from excessive friction
If you develop unexplained blisters or sores, consider retesting
Follow up with your dermatologist if symptoms persist despite negative results
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