Cardiovascular diseases are conditions affecting the heart and blood vessels, including coronary artery disease, heart attacks, stroke, and arrhythmias. These diseases are caused by atherosclerosis (plaque buildup in arteries), genetic mutations like MTHFR that elevate homocysteine, environmental toxins like mercury, and elevated TMAO (trimethylamine N-oxide) from gut bacteria. The TMAO test is the most important screening test for cardiovascular disease risk because it directly measures a metabolite that promotes arterial plaque formation.
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Cardiovascular disease is caused by a combination of factors including atherosclerosis (fatty plaque buildup in arteries), genetic mutations, environmental toxins, and metabolic abnormalities. Specific causes include elevated TMAO produced by gut bacteria that promotes plaque formation, MTHFR gene mutations that increase homocysteine levels, mercury exposure from contaminated fish or dental amalgams, chronic cocaine use that damages heart muscle and blood vessels, and ineffective aspirin therapy that fails to prevent blood clots. Lifestyle factors like poor diet, smoking, lack of exercise, and chronic stress also contribute to cardiovascular disease development by promoting inflammation and arterial damage.
The TMAO (Trimethylamine N-Oxide) test is the most important emerging test for cardiovascular disease risk because it measures a gut bacteria metabolite that directly promotes atherosclerosis and arterial plaque formation, predicting heart attack and stroke risk beyond traditional cholesterol tests. The MTHFR Mutation test is essential for identifying genetic predisposition to elevated homocysteine, a major risk factor for heart disease, stroke, and peripheral vascular disease. The Mercury Blood test detects toxic metal exposure linked to increased heart attack and coronary disease risk. If you are taking aspirin for heart protection, the AspirinWorks 11-dhTXB2 test is the best way to verify your aspirin is actually working to prevent blood clots. These specialized tests complement standard lipid panels by revealing hidden cardiovascular risks that traditional testing might miss.
You should get tested if you have a family history of heart disease, stroke, or early heart attacks (before age 55 in men or 65 in women). Get tested if you experience chest pain, shortness of breath, irregular heartbeat, unexplained fatigue, or dizziness. Testing is important if you have risk factors like high blood pressure, diabetes, obesity, smoking history, or high stress levels. If you are taking aspirin for heart protection, you should test to ensure it is working effectively. Testing is also recommended if you eat a diet high in red meat and eggs (which produce TMAO), have had significant mercury exposure from fish consumption or dental work, or if you use or have used cocaine regularly, as these factors significantly increase cardiovascular risk.
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What this means
Your TMAO level is elevated, which may indicate increased cardiovascular risk. Higher TMAO levels have been associated with greater risk of heart attacks, strokes, and other cardiac events. This suggests your gut bacteria may be producing excess TMAO from your current diet, particularly from red meat, eggs, or high-fat animal products.
Recommended actions
Reduce consumption of red meat, egg yolks, and high-fat dairy products
Increase plant-based foods like fruits, vegetables, whole grains, and legumes
Consider taking probiotics or eating fermented foods to support healthier gut bacteria
Retest in 3-6 months after implementing dietary changes
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