Autoimmune Thyroid Disease Blood Test

What is Autoimmune Thyroid Diseases?

Autoimmune thyroid diseases are conditions where the immune system mistakenly attacks the thyroid gland, causing either underactive thyroid (Hashimoto's thyroiditis) or overactive thyroid (Graves' disease). They are caused by abnormal production of thyroid antibodies including thyroid peroxidase antibodies (TPO) and thyroglobulin antibodies that damage thyroid tissue. The ANA Screen IFA with Reflex to Titer and Pattern is the most important complementary test for detecting broader autoimmune activity associated with thyroid disease.

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What causes autoimmune thyroid disease?

Autoimmune thyroid disease is caused by the immune system producing antibodies that attack the thyroid gland. In Hashimoto's thyroiditis, thyroid peroxidase antibodies (TPO) and thyroglobulin antibodies destroy thyroid cells, leading to hypothyroidism. In Graves' disease, thyroid-stimulating immunoglobulins (TSI) overstimulate the thyroid, causing hyperthyroidism. Genetic factors, environmental triggers, and hormonal changes can all contribute to developing these autoimmune conditions.

What is the best test for autoimmune thyroid disease?

The ANA Screen IFA with Reflex to Titer and Pattern is the most important complementary test for autoimmune thyroid disease because it detects antinuclear antibodies that indicate broader autoimmune activity in your body. This test helps identify if your immune system is producing antibodies against your own tissues, which is common in people with Hashimoto's thyroiditis and Graves' disease. Your doctor will also order thyroid-specific antibody tests like TPO and thyroglobulin antibodies, along with thyroid function tests (TSH, Free T3, Free T4) to get a complete picture of your thyroid health and autoimmune status.

When should I get tested for autoimmune thyroid disease?

You should get tested if you experience unexplained weight changes, persistent fatigue, sensitivity to heat or cold, irregular heartbeat, or changes in mood and energy levels. Testing is also important if you have a family history of thyroid problems, are pregnant or planning pregnancy, or have been diagnosed with another autoimmune condition like type 1 diabetes or celiac disease. Women over 60 and people with other autoimmune conditions are at higher risk and should consider regular screening even without obvious symptoms.

What are the symptoms of autoimmune thyroid disease?
Hashimoto's thyroiditis symptoms include fatigue, weight gain, cold sensitivity, dry skin, hair loss, constipation, muscle weakness, and depression. Graves' disease symptoms include weight loss despite increased appetite, rapid or irregular heartbeat, nervousness or anxiety, heat sensitivity, sweating, trembling hands, and bulging eyes. Both conditions can cause an enlarged thyroid (goiter), menstrual irregularities, and difficulty concentrating. Symptoms develop gradually and are often mistaken for stress or aging.
Who is at risk for autoimmune thyroid disease?
Women are 5-10 times more likely to develop autoimmune thyroid disease than men, especially between ages 30-50. People with a family history of thyroid disease or other autoimmune conditions like rheumatoid arthritis, lupus, or type 1 diabetes have increased risk. Other risk factors include pregnancy (postpartum thyroiditis), excessive iodine intake, radiation exposure to the neck, certain medications, and having other autoimmune disorders. Smoking significantly increases the risk of Graves' disease and associated eye problems.
What happens if autoimmune thyroid disease is left untreated?
Untreated Hashimoto's thyroiditis can lead to severe hypothyroidism, causing heart problems, high cholesterol, infertility, birth defects during pregnancy, nerve damage, and myxedema coma in extreme cases. Untreated Graves' disease can result in heart rhythm disorders, osteoporosis, vision problems or blindness from eye disease, and thyroid storm, a life-threatening condition. Both conditions significantly impact quality of life and increase the risk of developing additional autoimmune diseases. Early diagnosis and treatment prevent these serious complications and help maintain normal metabolism and energy levels.
Can autoimmune thyroid disease be diagnosed with a blood test?
Yes, autoimmune thyroid disease is primarily diagnosed through blood tests that measure thyroid function and antibodies. Blood tests check TSH (thyroid-stimulating hormone), Free T4, and Free T3 to assess thyroid function, while antibody tests detect TPO antibodies, thyroglobulin antibodies, and TSI antibodies. The ANA Screen test helps identify broader autoimmune activity. Your doctor may also order imaging tests like thyroid ultrasound to evaluate the gland's size and structure, but blood tests provide the definitive diagnosis of autoimmune thyroid disease.
How is autoimmune thyroid disease treated?
Hashimoto's thyroiditis is treated with daily thyroid hormone replacement medication (levothyroxine) to restore normal thyroid levels and relieve symptoms. Graves' disease treatment includes antithyroid medications to reduce hormone production, radioactive iodine therapy to destroy overactive thyroid cells, or surgery to remove part or all of the thyroid gland. Beta-blockers may be prescribed to manage rapid heartbeat and tremors. Treatment is lifelong for most patients, requiring regular blood tests to monitor thyroid levels and adjust medication dosages as needed.
How can I prevent autoimmune thyroid disease?
While autoimmune thyroid disease cannot be completely prevented due to genetic factors, you can reduce your risk by maintaining adequate but not excessive iodine intake, avoiding smoking, managing stress through exercise and relaxation techniques, and getting regular checkups if you have a family history. If you have another autoimmune condition, work with your doctor to monitor thyroid function regularly. Early detection through screening allows for prompt treatment before symptoms become severe, preventing long-term complications and maintaining quality of life.
What natural remedies help with autoimmune thyroid disease?
While natural remedies cannot replace medical treatment, certain lifestyle changes support thyroid health alongside prescribed medications. Eating a nutrient-rich diet with selenium (from Brazil nuts and fish), zinc, and vitamin D helps support immune function. Reducing gluten intake may benefit some people with Hashimoto's, as celiac disease often coexists with thyroid autoimmunity. Regular exercise, stress management through yoga or meditation, and adequate sleep help regulate metabolism and reduce inflammation. Always consult your doctor before taking supplements, as some can interfere with thyroid medication absorption.
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Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

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If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
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What this means

Your ANA test came back negative, meaning no antinuclear antibodies were detected in your blood. This is the expected and healthy result, suggesting that an autoimmune condition is less likely to be causing your symptoms.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

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* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

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ANA Screen IFA w/ Ref to Titer and Pattern
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