Autoimmune Disease Blood Test

What is Autoimmune diseases?

Autoimmune diseases occur when the immune system mistakenly attacks healthy tissues and organs in the body. They are caused by the production of autoantibodies that target the body's own cells, leading to conditions like rheumatoid arthritis, lupus, and Sjögren's syndrome. The IgG, IgA, Indirect Immunofluorescence test is the most important test for diagnosis because it detects the autoantibodies responsible for tissue damage.

RECOMMENDED TEST IgG, IgA, Indirect Immunofluorescence
What's included
Fast & easy, results by email & SMS
No extra fees paid at the lab
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
Why Private MD Labs?
90-day money-back guarantee Lab order in minutes Save a trip to the doctor Low prices since 2005 Labs within 2 miles

What causes autoimmune diseases?

Autoimmune diseases are caused by the immune system producing autoantibodies that mistakenly attack the body's own healthy tissues and organs. While the exact trigger varies by condition, genetic factors, environmental exposures, infections, and hormonal changes can all contribute to immune system dysfunction. In rheumatoid arthritis, autoantibodies attack joint tissues, while in lupus, they target multiple organs including the skin, kidneys, and heart.

What is the best test for autoimmune diseases?

The IgG, IgA, Indirect Immunofluorescence test is the most important test for autoimmune diseases because it detects autoantibodies commonly associated with lupus, Sjögren's syndrome, and rheumatoid arthritis. This test uses indirect immunofluorescence to identify antibodies attacking your own tissues, while elevated IgG levels indicate an overactive immune response. The Lymphocyte Subset Panel 4 (CD4:CD8 Ratio Profile) is also essential as it measures the ratio of CD4 to CD8 immune cells, which is often elevated in autoimmune conditions due to excess CD4 cells contributing to tissue damage.

When should I get tested for autoimmune diseases?

You should get tested if you experience persistent joint pain and stiffness, unexplained fatigue that doesn't improve with rest, recurring fevers without infection, skin rashes that come and go, or swelling in multiple joints. Testing is especially important if you have a family history of autoimmune diseases or if your symptoms have lasted more than six weeks and affect your daily activities. Early detection through blood tests can help prevent serious organ damage and improve treatment outcomes.

What are the symptoms of autoimmune diseases?
Autoimmune disease symptoms vary depending on which organs are affected but commonly include chronic fatigue, joint pain and swelling, muscle aches, recurring low-grade fevers, and skin rashes or sensitivity. You might notice brain fog, difficulty concentrating, unexplained weight changes, digestive issues, or numbness and tingling in your hands and feet. Many people experience flare-ups where symptoms worsen followed by periods of remission, making the pattern unpredictable and challenging to manage without proper diagnosis.
Who is at risk for autoimmune diseases?
Women are at significantly higher risk for autoimmune diseases, accounting for nearly 80% of cases, with the highest risk during childbearing years. You face increased risk if you have family members with autoimmune conditions, certain ethnic backgrounds (particularly African American, Hispanic, or Native American descent), or have been exposed to specific infections or environmental toxins. People with one autoimmune disease are also more likely to develop additional autoimmune conditions over time.
What happens if autoimmune diseases are left untreated?
Untreated autoimmune diseases can cause permanent organ damage and life-threatening complications. In rheumatoid arthritis, ongoing joint inflammation leads to irreversible bone erosion and deformity, while untreated lupus can cause kidney failure, heart disease, and stroke. Autoimmune conditions can also trigger secondary problems like increased infection risk, osteoporosis, cardiovascular disease, and even certain cancers. Early diagnosis and treatment are crucial to prevent these serious complications and maintain quality of life.
Can autoimmune diseases be diagnosed with a blood test?
Autoimmune diseases can be diagnosed through specialized blood tests that detect autoantibodies, measure immune cell populations, and identify inflammation markers. The IgG, IgA, Indirect Immunofluorescence test detects autoantibodies attacking your tissues, while the CD4:CD8 Ratio Profile measures immune cell imbalances characteristic of autoimmune conditions. Blood tests also measure inflammation markers like AST levels and can track disease activity over time, though diagnosis typically requires multiple tests combined with clinical evaluation of your symptoms.
How are autoimmune diseases treated?
Autoimmune diseases are treated with medications that suppress the overactive immune response and reduce inflammation. Your doctor may prescribe corticosteroids to control acute flares, disease-modifying antirheumatic drugs (DMARDs) to slow disease progression, or biologic therapies that target specific immune system components. Treatment also includes managing symptoms with pain relievers, physical therapy to maintain joint function, and lifestyle modifications like stress reduction, regular exercise, and an anti-inflammatory diet to support overall health.
How can I prevent autoimmune diseases?
While you cannot completely prevent autoimmune diseases if you have genetic risk factors, you can reduce your risk by avoiding known triggers like smoking, excessive sun exposure, and certain medications. Maintaining a healthy weight, eating an anti-inflammatory diet rich in omega-3 fatty acids and vegetables, managing stress through meditation or yoga, and getting adequate sleep all support immune system balance. Early detection through blood testing when symptoms first appear can help prevent progression and serious complications.
What natural remedies help with autoimmune diseases?
Natural approaches that help manage autoimmune disease symptoms include following an anti-inflammatory diet with fatty fish, leafy greens, berries, and turmeric while avoiding processed foods and excess sugar. Omega-3 supplements, vitamin D, and probiotics support immune system regulation, though you should consult your doctor before starting any supplements. Regular moderate exercise, stress management techniques like meditation or deep breathing, adequate sleep, and avoiding smoking and excessive alcohol can all help reduce inflammation and improve symptom control alongside medical treatment.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
Anti-Epithelial Cell Surface Antibodies (IgG) Negative
Demo results
Negative Positive
Negative

What this means

Your test came back negative, meaning no anti-epithelial cell surface antibodies were detected in your blood. This is the expected and healthy result, suggesting no active autoimmune blistering disease affecting the connections between skin cells.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

Us vs. Them

Not overhyped or overpriced. Just comprehensive blood testing made simple and for everyone.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

1,000,000+ blood tests later, here's what our customers say

Google reviews 3303 reviews Next
IgG, IgA, Indirect Immunofluorescence
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

Sample results

Sample image
For you & your coach Health insights Written in human language, backed by science.
Sample image
For you & your doc Classic lab report A familiar and comprehensive lab report.

Ask Me Anything

Your 24/7 Personal Lab Guide

Quick questions:

Which test is right for my symptoms?
What could be causing this?
When should I get tested?
A

Hi, I'm here to make labs simple, clear, and stress-free. Not sure where to start? That's okay. Tell me what's going on and I'll guide you from there.

I can help you:

  • choose the right test
  • prepare for your lab visit
  • take the next step with confidence and more
Just now
A
Not finding what you need? Text 754-799-7833, we've got you.
We provide helpful guidance, not medical diagnoses. For medical decisions, consult a licensed professional.