Autoimmune Disease Blood Test

What is Autoimmune Disease?

Autoimmune diseases occur when the immune system mistakenly attacks healthy cells and tissues instead of foreign invaders. They are caused by immune system dysfunction where antibodies and immune proteins target the body's own organs and systems. The Liver Function Profile is the most important test for autoimmune disease screening because it measures globulin proteins that elevate when the immune system mounts an inflammatory response against its own tissues.

RECOMMENDED TEST Liver Function Profile
What's included
Fast & easy, results by email & SMS
No extra fees paid at the lab
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
Why Private MD Labs?
90-day money-back guarantee Lab order in minutes Save a trip to the doctor Low prices since 2005 Labs within 2 miles

What causes autoimmune disease?

Autoimmune diseases are caused by immune system dysfunction where your body produces antibodies and immune cells that attack healthy tissues instead of foreign invaders like bacteria or viruses. The exact trigger varies by condition, but genetic factors, environmental exposures, infections, and hormonal changes can all contribute to the immune system losing its ability to distinguish between self and non-self. Common autoimmune conditions include rheumatoid arthritis, lupus, multiple sclerosis, type 1 diabetes, and celiac disease, each targeting different organs or body systems.

What is the best test for autoimmune disease?

The Liver Function Profile is the most important test for autoimmune disease screening because it measures globulin proteins that elevate dramatically when your immune system attacks your own tissues. Elevated globulin levels serve as a red flag for autoimmune activity. The Protein Electrophoresis and Kappa/Lambda Light Chains test is essential for deeper evaluation, as it separates different blood proteins including gamma globulins that increase during autoimmune responses. Additionally, the Rubella Immune Status and Measles Antibody tests can reveal abnormally high antibody levels indicating immune system overactivity and dysfunction characteristic of autoimmune processes.

When should I get tested for autoimmune disease?

You should get tested if you experience persistent unexplained fatigue, joint pain or swelling, recurring fevers, skin rashes, digestive issues, or muscle weakness that lasts for weeks or months. Testing is especially important if you have a family history of autoimmune conditions, notice symptoms that come and go in flare-ups, or have multiple seemingly unrelated health issues affecting different body systems. Early detection through blood testing helps identify autoimmune activity before significant organ damage occurs and allows for prompt treatment to manage symptoms and prevent progression.

What are the symptoms of autoimmune disease?
Autoimmune disease symptoms vary widely depending on which organs or systems are affected, but common signs include chronic fatigue that does not improve with rest, joint pain and stiffness, muscle aches and weakness, recurring low-grade fevers, skin rashes or color changes, hair loss, digestive problems, numbness and tingling in hands and feet, brain fog and difficulty concentrating, and unexplained weight changes. Many people experience symptom flare-ups followed by periods of remission. Because symptoms often overlap with other conditions and can affect multiple body systems simultaneously, blood tests are essential for identifying the underlying autoimmune process.
Who is at risk for autoimmune disease?
Women are at significantly higher risk for autoimmune diseases, accounting for about 80% of cases, with peak onset typically occurring during childbearing years. People with a family history of autoimmune conditions have increased susceptibility due to genetic factors. Certain ethnic groups face elevated risk, including African Americans, Hispanics, and Native Americans. Environmental factors like smoking, exposure to chemicals or toxins, certain infections, and chronic stress can trigger autoimmune responses in genetically predisposed individuals. Having one autoimmune disease increases your risk of developing additional autoimmune conditions.
What happens if autoimmune disease is left untreated?
Untreated autoimmune diseases cause progressive damage to affected organs and tissues as the immune system continues its attack unchecked. This can lead to permanent organ dysfunction, chronic pain, severe disability, and life-threatening complications depending on which systems are involved. For example, untreated rheumatoid arthritis destroys joints, untreated lupus damages kidneys and heart, and untreated type 1 diabetes causes dangerous blood sugar fluctuations. Chronic inflammation from autoimmune activity increases risk for cardiovascular disease, osteoporosis, infections, and certain cancers. Early diagnosis through blood testing and prompt treatment prevents or slows irreversible damage.
Can autoimmune disease be diagnosed with a blood test?
Blood tests are essential tools for diagnosing autoimmune diseases by detecting immune markers, measuring inflammatory proteins, and identifying specific antibodies that attack your own tissues. Tests like the Liver Function Profile reveal elevated globulin proteins indicating immune system activation, while Protein Electrophoresis measures gamma globulin levels that rise during autoimmune responses. However, diagnosis typically requires multiple blood tests combined with your symptom history, physical examination, and sometimes imaging or tissue biopsies. No single blood test diagnoses all autoimmune conditions, but specific antibody tests exist for individual diseases like antinuclear antibodies for lupus or rheumatoid factor for rheumatoid arthritis.
How is autoimmune disease treated?
Autoimmune disease treatment focuses on suppressing the overactive immune response, reducing inflammation, and managing symptoms to prevent organ damage. Immunosuppressive medications like corticosteroids, methotrexate, and biologics help control the immune system attack. Anti-inflammatory drugs reduce pain and swelling. Disease-modifying antirheumatic drugs slow disease progression. Treatment plans are highly individualized based on which autoimmune condition you have, symptom severity, and affected organs. Regular blood tests monitor disease activity and treatment effectiveness. Lifestyle modifications including stress management, adequate sleep, regular exercise, and an anti-inflammatory diet support medical treatment.
How can I prevent autoimmune disease?
While you cannot completely prevent autoimmune diseases if you have genetic susceptibility, you can reduce risk and delay onset by avoiding known triggers. Stop smoking, which significantly increases autoimmune disease risk. Minimize exposure to environmental toxins and chemicals. Maintain a healthy diet rich in anti-inflammatory foods like fruits, vegetables, fatty fish, and whole grains while limiting processed foods and sugar. Manage stress through meditation, yoga, or counseling. Get adequate sleep and regular moderate exercise. Address infections promptly. Maintain a healthy weight and gut microbiome through probiotics and fermented foods. Regular blood testing helps detect early autoimmune markers before symptoms develop.
What natural remedies help with autoimmune disease?
Natural approaches can complement medical treatment for autoimmune diseases by reducing inflammation and supporting immune system balance. Omega-3 fatty acids from fish oil reduce inflammatory responses. Vitamin D supplementation improves immune regulation, as many autoimmune patients are deficient. Turmeric and curcumin have powerful anti-inflammatory properties. Probiotics support gut health, which plays a crucial role in immune function. Adaptogenic herbs like ashwagandha help manage stress that triggers flare-ups. Regular gentle exercise like walking, swimming, or yoga reduces inflammation without overtaxing your body. However, natural remedies should supplement, not replace, medical treatment prescribed by your healthcare provider based on your blood test results.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
Here’s how easy it is to get blood work done on your terms
Choose a checkup
Order your test Save a trip to the doctor. Your results will come with clear, friendly explanations. Takes 2 minutes
Book a lab
Book an appointment Visit any of our 4,000 nearby lab locations to have your samples collected. Book or walk-in
Choose a checkup
Get results Receive a clear, easy-to-digest health report by email & SMS within a few business days. Get answers, fast

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

You get clinical lab reports & simplified health insights.
Save time & gas, go straight to the lab. Our doctors cover the rest.
Results start landing the next day after your lab visit.*
We don’t sell or share your data. Your time & privacy matter.
US-licensed doctors have your back if things get unclear.
No hidden fees, nice discounts for regular checkups.
Save a trip to the doctor, go directly to the lab
Instant orders, results often overnight*
Results explained in simple language
Reviewed by US licensed doctors
Fast & confidential, we never sell or share your data
No insurance needed, transparent pricing
Demo results
ALT (Alanine Aminotransferase) 52 U/L
Demo results
Low Optimal 7 - 45 High
52 U/L

What this means

Your ALT level is slightly elevated above the optimal range, which may indicate mild liver inflammation or stress. This is commonly seen with fatty liver, alcohol use, certain medications, or metabolic conditions, and while not immediately alarming, it suggests your liver could benefit from some extra support.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

Us vs. Them

Not overhyped or overpriced. Just comprehensive blood testing made simple and for everyone.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

1,000,000+ blood tests later, here's what our customers say

Google reviews 3303 reviews Next
Liver Function Profile
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

Sample results

Sample image
For you & your coach Health insights Written in human language, backed by science.
Sample image
For you & your doc Classic lab report A familiar and comprehensive lab report.

Ask Me Anything

Your 24/7 Personal Lab Guide

Quick questions:

Which test is right for my symptoms?
What could be causing this?
When should I get tested?
A

Hi, I'm here to make labs simple, clear, and stress-free. Not sure where to start? That's okay. Tell me what's going on and I'll guide you from there.

I can help you:

  • choose the right test
  • prepare for your lab visit
  • take the next step with confidence and more
Just now
A
Not finding what you need? Text 754-799-7833, we've got you.
We provide helpful guidance, not medical diagnoses. For medical decisions, consult a licensed professional.