Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Atrophic thyroiditis is a form of Hashimoto's thyroiditis, an autoimmune condition where the body's immune system attacks the thyroid gland. Unlike classic Hashimoto's, atrophic thyroiditis does not cause thyroid enlargement (goiter) but leads to thyroid shrinkage and reduced function over time.
This test measures antibodies against thyroid peroxidase, an enzyme crucial for thyroid hormone production. Elevated TPO antibodies in the blood indicate an autoimmune attack on the thyroid gland, which is characteristic of atrophic thyroiditis. High levels of these antibodies help confirm the diagnosis and distinguish this condition from other forms of thyroid dysfunction.
Because atrophic thyroiditis is an autoimmune condition, specific blood tests that detect antibodies against thyroid tissue are essential for diagnosis. These antibody tests help distinguish autoimmune thyroid disease from other causes of hypothyroidism and guide appropriate treatment decisions.
TPO antibody testing is typically performed alongside thyroid function tests (TSH, T3, T4) to provide a complete picture of thyroid health. Positive TPO antibodies combined with elevated TSH levels often confirm the diagnosis of atrophic thyroiditis and help healthcare providers determine the most appropriate treatment approach.
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.