Atherosclerosis Blood Test

What is Atherosclerosis?

Atherosclerosis is a condition where arteries become hardened and narrowed due to plaque buildup consisting of cholesterol, fatty substances, and other materials. It is caused by elevated LDL cholesterol, inflammation, and oxidized lipoproteins that penetrate and accumulate in arterial walls. The Lipid Panel is the most important test for diagnosis because it measures LDL cholesterol and other lipid levels that directly contribute to plaque formation.

RECOMMENDED TEST Lipid Panel
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Fast & easy, results by email & SMS
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What causes atherosclerosis?

Atherosclerosis is caused by elevated LDL cholesterol, chronic inflammation, and oxidized lipoproteins that penetrate the inner lining of artery walls. When LDL cholesterol particles become oxidized, they trigger an inflammatory response that attracts white blood cells to the arterial wall, leading to plaque formation. Over time, this plaque hardens and narrows the arteries, restricting blood flow to vital organs and increasing the risk of heart attack and stroke.

What is the best test for atherosclerosis?

The Lipid Panel is the most important test for atherosclerosis because it measures total cholesterol, LDL cholesterol, HDL cholesterol, and triglycerides that directly contribute to plaque buildup in arteries. For a more comprehensive assessment, the Lipid Panel with Ratios provides critical LDL/HDL ratios that indicate your cardiovascular risk level. Advanced testing options like the Cardio IQ Advanced Lipid Panel measure Apolipoprotein B and other specialized markers that identify even more precise risk factors. The sdLDL(7) test is especially valuable because it detects small, dense LDL particles that penetrate arterial walls more easily and are highly atherogenic.

When should I get tested for atherosclerosis?

You should get tested if you have a family history of heart disease, high cholesterol, diabetes, high blood pressure, or if you are a smoker. Adults over 40 should have their lipid levels checked regularly, even without symptoms, since atherosclerosis develops silently over years. You should also consider testing if you experience chest pain, shortness of breath during physical activity, or have been told you have metabolic syndrome, as these are warning signs of advancing arterial disease.

What are the symptoms of atherosclerosis?
Atherosclerosis often develops without symptoms until arteries become severely narrowed or blocked. When symptoms do appear, they depend on which arteries are affected and may include chest pain or pressure (angina), shortness of breath, leg pain when walking (claudication), numbness or weakness in arms or legs, difficulty speaking, or drooping facial muscles if brain arteries are affected. Many people discover they have atherosclerosis only after experiencing a heart attack or stroke, which is why preventive blood testing is so important.
Who is at risk for atherosclerosis?
People with high LDL cholesterol, low HDL cholesterol, high blood pressure, diabetes, and smokers are at increased risk for atherosclerosis. Your risk also increases if you have a family history of early heart disease, are overweight or obese, lead a sedentary lifestyle, or have chronic kidney disease. Men over 45 and women over 55 face higher risk, as do individuals with inflammatory conditions like rheumatoid arthritis or lupus. Genetic factors, including the ApoE4 variant, can significantly increase your predisposition to developing arterial plaque.
What happens if atherosclerosis is left untreated?
Untreated atherosclerosis progressively narrows arteries and can lead to life-threatening complications including heart attack, stroke, peripheral artery disease, and aneurysms. When plaque ruptures, it can trigger blood clots that completely block blood flow, causing sudden cardiac death or massive stroke. Reduced blood flow to the kidneys can cause kidney failure, while blocked arteries in the legs may require amputation in severe cases. Early detection through blood testing allows you to take action before these irreversible complications occur.
Can atherosclerosis be diagnosed with a blood test?
Blood tests cannot directly visualize atherosclerosis, but they are essential for identifying the risk factors that cause plaque formation and for monitoring disease progression. Tests like the Lipid Panel, Direct LDL, and advanced lipid panels measure cholesterol levels and particle counts that directly correlate with atherosclerosis risk. Inflammatory markers like Interleukin-1 Beta and fibrinogen levels indicate ongoing arterial inflammation. Genetic testing such as ApoE Genotype helps identify inherited predispositions. When combined with imaging studies, blood tests provide a comprehensive assessment of your cardiovascular health.
How is atherosclerosis treated?
Atherosclerosis is treated through lifestyle changes, medications, and in severe cases, surgical procedures. Statins are commonly prescribed to lower LDL cholesterol and stabilize existing plaques, while other medications control blood pressure, prevent blood clots, and manage diabetes. Lifestyle modifications include adopting a heart-healthy diet low in saturated fats, exercising regularly, quitting smoking, and maintaining a healthy weight. Severe blockages may require angioplasty with stent placement or bypass surgery to restore blood flow. Regular blood testing helps monitor treatment effectiveness and adjust medications as needed.
How can I prevent atherosclerosis?
You can prevent atherosclerosis by maintaining healthy cholesterol levels through diet, regular exercise, and avoiding smoking. Eat a diet rich in fruits, vegetables, whole grains, and omega-3 fatty acids while limiting saturated fats, trans fats, and processed foods. Aim for at least 150 minutes of moderate aerobic exercise weekly and maintain a healthy weight. Control blood pressure and blood sugar levels if you have hypertension or diabetes. Get regular lipid panel testing to catch elevated cholesterol early, and work with your healthcare provider to address risk factors before arterial damage occurs.
What natural remedies help with atherosclerosis?
Natural approaches that support arterial health include consuming omega-3 fatty acids from fish oil, which reduce inflammation and triglyceride levels. Plant sterols and stanols found in fortified foods can help lower LDL cholesterol, while soluble fiber from oats, beans, and fruits binds cholesterol in the digestive system. Garlic, green tea, and foods rich in antioxidants like berries may help protect LDL cholesterol from oxidation. Regular physical activity naturally raises HDL cholesterol and improves circulation. While these natural strategies can support cardiovascular health, they should complement rather than replace medical treatment and regular blood testing.
How’s this work?
Getting your blood test with us is easy, private & backed by the power of science.

Long story short:
  1. In the test options, use the filters or search box to narrow your choices and find the test you want.
  2. If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
  3. Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
  4. If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
  5. When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
  6. Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
  7. You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
  8. If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
How do I know which test to get?
In the test options, find the test you want. If you’re not sure which test to get, we can lend a hand in finding the right option.

Just text or call us at 754-799-7833, email us at [email protected], and we'll gladly help you. We've got your back and reply quickly.
Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

Our lab requires an address to be listed to generate an order.
Do you accept health insurance?
Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
Can I cancel my order?
Yes.

We get it – sometimes your needs change.

As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

If you have any further questions, please text us at 754-799-7833 or email [email protected].

You can read more about our cancellation policy here.
How can I find a lab location near me?
During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.

If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
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HDL Cholesterol 38 mg/dL
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Low < 45 Optimal ≄ 45
38 mg/dL

What this means

Your HDL (good cholesterol) is below the recommended level. Higher HDL helps protect against heart disease by removing harmful cholesterol from your arteries. This is an area where lifestyle changes can make a significant positive impact on your heart health.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

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* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

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Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

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