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Aortic valve stenosis is a heart condition where the aortic valve narrows and restricts blood flow from the heart to the rest of the body. It is caused by progressive calcification of the valve leaflets, often accelerated by elevated lipoprotein(a) levels. The Lipoprotein(a) test is the most important blood test for assessing cardiovascular risk factors that contribute to valve calcification and stenosis progression.
Aortic valve stenosis is caused by progressive calcification and thickening of the aortic valve leaflets, which narrows the valve opening and restricts blood flow. The most common cause in older adults is age-related calcium buildup on the valve, similar to hardening of the arteries. Elevated lipoprotein(a) levels significantly accelerate this calcification process by depositing calcium on the valve tissue. In younger people, congenital heart defects like bicuspid aortic valve or rheumatic fever from untreated strep infections can also cause valve damage and stenosis over time.
The Lipoprotein(a) test is the most important blood test for aortic valve stenosis because it measures a specific lipoprotein strongly linked to valve calcification and disease progression. Elevated lipoprotein(a) levels directly contribute to calcium deposits forming on the aortic valve, making this test essential for assessing your cardiovascular risk factors. While aortic valve stenosis is primarily diagnosed through echocardiograms and imaging studies that visualize the valve structure and blood flow, the Lipoprotein(a) blood test helps identify patients at higher risk for developing or worsening stenosis. This information allows your healthcare provider to monitor progression and develop strategies to manage risk factors that accelerate valve deterioration.
You should get tested if you experience symptoms like chest pain or pressure during physical activity, shortness of breath with exertion or when lying down, fatigue, dizziness, or fainting episodes. Testing is also important if you have a heart murmur detected during a physical exam, a family history of heart valve disease, or known risk factors like high cholesterol or elevated lipoprotein(a) levels. If you were born with a bicuspid aortic valve or had rheumatic fever as a child, regular monitoring is essential even without symptoms, as these conditions significantly increase your risk for developing stenosis over time.
What this means
Your lipoprotein(a) level is elevated, which indicates an increased genetic risk for heart disease. While this is not immediately dangerous, elevated Lp(a) can accelerate plaque buildup in your arteries over time and increase your risk for heart attacks and strokes even if your other cholesterol numbers are normal.
Recommended actions
Focus on aggressively managing other heart risk factors like LDL cholesterol and blood pressure
Adopt a heart-healthy Mediterranean diet rich in fish, olive oil, vegetables, and whole grains
Engage in regular cardiovascular exercise like brisk walking, cycling, or swimming for 30+ minutes most days
Discuss your results with your doctor to create a comprehensive heart disease prevention plan
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