Understanding Lab Tests for Antiphospholipid Syndrome
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Antiphospholipid Syndrome (APS) is an autoimmune disorder where the body produces antibodies that interfere with the normal blood clotting process. This condition can lead to an increased risk of blood clots in veins and arteries, as well as pregnancy complications. Diagnosis requires specific blood tests to detect the presence of antiphospholipid antibodies and assess their impact on clotting function.
Recommended Test
Prothrombin Time (PT) (INR) and Partial Thromboplastin Time (PTT)
This comprehensive coagulation panel measures how long it takes for blood to clot through different pathways. In Antiphospholipid Syndrome, the autoimmune antibodies can interfere with the clotting process, often causing a prolonged PTT. These tests are fundamental for assessing the functional impact of antiphospholipid antibodies on blood coagulation and monitoring patients on anticoagulant therapy.
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How Blood Tests Help Diagnose Antiphospholipid Syndrome
While the primary diagnosis of APS relies on detecting specific antiphospholipid antibodies through specialized testing, coagulation studies are essential for evaluating how these antibodies affect blood clotting function. These tests help healthcare providers understand the severity of clotting abnormalities and guide treatment decisions.
Understanding Your Results
Prolonged clotting times, particularly an elevated PTT, may suggest the presence of antiphospholipid antibodies interfering with normal coagulation. However, these results must be interpreted alongside clinical symptoms and additional specialized antibody testing for a complete diagnosis of Antiphospholipid Syndrome.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.
