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Androgen deficiency is a condition where the body produces inadequate levels of male hormones, primarily testosterone. It is caused by testicular dysfunction, pituitary gland problems, or hypothalamic disorders that disrupt testosterone production. The Testosterone, Free, Bioavailable and Total, LC/MS/MS test is the most important test for diagnosis because it measures all forms of testosterone in the blood.
Androgen deficiency is caused by problems with the testicles, pituitary gland, or hypothalamus that disrupt testosterone production. Primary causes include testicular injury, infection, chemotherapy, or genetic conditions like Klinefelter syndrome. Secondary causes involve pituitary tumors, obesity, chronic illness, certain medications (especially opioids and steroids), or age-related decline in hormone production. Stress, poor sleep, and excessive alcohol consumption can also contribute to low testosterone levels.
The Testosterone, Free, Bioavailable and Total, LC/MS/MS test is the most important test for androgen deficiency because it measures all three forms of testosterone: total testosterone (all testosterone in your blood), free testosterone (immediately available and active), and bioavailable testosterone (free plus loosely bound testosterone that can be used by your body). This comprehensive assessment using highly accurate LC/MS/MS technology provides the complete picture doctors need to diagnose androgen deficiency and guide treatment decisions. Testing should be done in the morning between 7-10 AM when testosterone levels are naturally highest.
You should get tested if you experience persistent fatigue, decreased sex drive, difficulty achieving or maintaining erections, loss of muscle mass, increased body fat (especially around the abdomen), mood changes like depression or irritability, or reduced bone density. Men over 40 with these symptoms should consider testing, as testosterone naturally declines with age. You should also get tested if you have chronic conditions like diabetes, obesity, or sleep apnea, or if you take medications known to affect testosterone levels.
What this means
Your total testosterone levels are slightly below the optimal range. While this is not necessarily cause for concern, it may contribute to occasional fatigue, reduced motivation, difficulty building muscle, or lower energy levels throughout the day.
Recommended actions
Increase resistance or strength training with compound exercises like squats and deadlifts
Prioritize 7-9 hours of quality sleep per night and manage stress levels
Include more zinc- and magnesium-rich foods like shellfish, beef, pumpkin seeds, and spinach
Consider retesting in 3-6 months to monitor trends and assess lifestyle changes
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