Understanding Lab Tests for Allograft Rejection
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Allograft rejection occurs when the immune system recognizes a transplanted organ as foreign and mounts an immune response against it. While definitive diagnosis typically requires tissue biopsy, blood tests play a crucial role in monitoring immune activity and detecting early signs of potential rejection.
Recommended Test
Interleukin-2 Receptor Alpha Chain (IL-2Ra/CD25), Soluble
This test measures levels of soluble IL-2Ra/CD25, a marker of immune system activation. In organ transplant recipients, elevated levels can indicate an active immune response against the transplanted organ, serving as an early warning sign of potential rejection that may require immediate medical attention and treatment modification.
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The Role of Blood Testing in Transplant Monitoring
Blood tests cannot definitively diagnose allograft rejection on their own, but they are fundamental for monitoring immune system activation and detecting biochemical markers that suggest an ongoing immune response against the transplanted organ. These tests help healthcare providers make timely decisions about treatment adjustments and further diagnostic procedures.
Understanding Test Results
Elevated IL-2Ra/CD25 levels suggest increased immune activity, which in transplant recipients may indicate the beginning stages of rejection. However, these results must be interpreted alongside clinical symptoms, other laboratory findings, and potentially tissue biopsy results to confirm the diagnosis and guide appropriate treatment.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Transplant recipients should work closely with their transplant team for proper monitoring and treatment. Always consult with a healthcare provider for diagnosis and treatment.
