Allergic Reaction Blood Test

What is Allergic Reaction?

An allergic reaction occurs when the immune system overreacts to a normally harmless substance called an allergen, causing symptoms ranging from mild skin irritation to severe respiratory distress. It is caused by the production of IgE and IgG4 antibodies in response to specific allergens such as foods, pollen, mold, or environmental triggers. The IgG4 Food Panel III is the most important test for diagnosing food allergies because it identifies specific IgG4 antibodies against multiple common food allergens including broccoli, grapes, green beans, onions, pineapple, and sugar beet seed.

RECOMMENDED TEST IgG4 Food Panel III
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What causes allergic reactions?

Allergic reactions are caused by the immune system producing IgE and IgG4 antibodies in response to harmless substances called allergens. Common allergens include food proteins like those found in peanuts, shellfish, eggs, milk, tree nuts, and soy, as well as environmental triggers such as pollen, dust mites, mold spores, pet dander, and insect venom. When your body encounters these allergens, it mistakenly identifies them as dangerous invaders and launches an immune response that releases histamine and other chemicals into your bloodstream, causing the symptoms you experience during an allergic reaction.

What is the best test for allergic reactions?

The IgG4 Food Panel III is the most important test for diagnosing food allergies because it identifies IgG4 antibodies against multiple common food allergens including broccoli, grapes, green beans, onions, pineapple, and sugar beet seed. This comprehensive panel helps pinpoint which specific foods are triggering delayed immune responses that cause symptoms like hives, itching, digestive issues, and respiratory problems. For environmental allergies, the Hemp Western Water IgE test is essential because it measures IgE antibodies that indicate immediate-type allergic reactions to specific plant allergens. These tests provide concrete answers about what substances your immune system is reacting to, allowing you to avoid triggers and develop an effective treatment plan.

When should I get tested for allergic reactions?

You should get tested if you experience unexplained hives, skin rashes, or itching after eating certain foods or being in specific environments. Testing is also important if you notice digestive problems like bloating, nausea, or diarrhea that occur regularly after meals, or if you have respiratory symptoms such as wheezing, shortness of breath, nasal congestion, or persistent coughing without an infection. Get tested urgently if you have ever experienced swelling of your lips, tongue, or throat, or if your symptoms are interfering with your daily life and you cannot identify the trigger. Early identification of allergens helps you avoid potentially dangerous exposures and prevents reactions from worsening over time.

What are the symptoms of allergic reactions?
Allergic reaction symptoms vary depending on the severity and type of allergen involved. Mild to moderate symptoms include skin reactions like hives, redness, itching, or eczema, digestive issues such as nausea, vomiting, cramping, or diarrhea, and respiratory problems including sneezing, runny nose, congestion, coughing, or wheezing. More severe reactions can cause swelling of the face, lips, tongue, or throat, difficulty breathing or tightness in the chest, dizziness or lightheadedness, and rapid heartbeat. Anaphylaxis is the most dangerous allergic reaction and causes a sudden drop in blood pressure, loss of consciousness, and can be life-threatening without immediate treatment with epinephrine.
Who is at risk for allergic reactions?
Anyone can develop allergies, but certain factors increase your risk. People with a family history of allergies, asthma, or eczema are more likely to develop allergic reactions because these conditions have a genetic component. Children are at higher risk than adults, though many outgrow food allergies as their immune systems mature. People with existing allergies are more likely to develop additional allergies over time. Those with asthma face increased risk of severe allergic reactions, particularly to food allergens. Individuals who have experienced previous allergic reactions are at risk for future episodes, especially if they continue exposure to known allergens. Environmental factors like pollution exposure and certain dietary patterns may also influence allergy development.
What happens if allergic reactions are left untreated?
Untreated allergic reactions can progressively worsen with each exposure to the allergen, potentially leading to more severe symptoms over time. Chronic exposure to unidentified allergens can cause persistent inflammation throughout your body, leading to conditions like chronic sinusitis, asthma, eczema, or digestive disorders. Repeated allergic reactions increase your risk of developing anaphylaxis, a life-threatening condition that causes severe breathing difficulty, dangerous drops in blood pressure, and loss of consciousness. Long-term inflammation from ongoing allergic reactions can damage tissues in your respiratory tract, digestive system, or skin. Without identifying and avoiding allergens, you may experience reduced quality of life due to constant discomfort, sleep disruption, and inability to participate in normal activities.
Can allergic reactions be diagnosed with a blood test?
Yes, blood tests are highly effective for diagnosing allergic reactions by measuring specific antibodies your immune system produces in response to allergens. IgE blood tests detect immediate-type allergies that cause rapid reactions within minutes to hours of exposure, while IgG4 blood tests identify delayed-type allergies that may not cause symptoms until hours or days after contact with the allergen. These blood tests can identify specific allergens from a wide range of foods, environmental substances, and other triggers without requiring you to be exposed to potential allergens during testing. Blood testing is particularly useful if you have severe eczema or skin conditions that make skin prick testing difficult, if you take medications that interfere with other allergy tests, or if you want to test for multiple allergens at once.
How are allergic reactions treated?
Allergic reaction treatment depends on the severity of symptoms and begins with complete avoidance of identified allergens whenever possible. Antihistamines like cetirizine, loratadine, or diphenhydramine effectively treat mild symptoms such as hives, itching, and sneezing by blocking histamine release. Nasal corticosteroid sprays and eye drops help manage respiratory and eye symptoms from environmental allergies. For moderate to severe reactions, your doctor may prescribe stronger medications like oral corticosteroids to reduce inflammation. People with a history of severe reactions must carry an epinephrine auto-injector at all times and use it immediately if anaphylaxis symptoms appear. Immunotherapy through allergy shots or sublingual tablets can gradually desensitize your immune system to specific allergens over time, reducing reaction severity.
How can I prevent allergic reactions?
Preventing allergic reactions starts with identifying your specific allergens through blood testing and then strictly avoiding those triggers. For food allergies, carefully read ingredient labels on all packaged foods, inform restaurants about your allergies when dining out, and avoid cross-contamination by using separate cooking utensils and preparation surfaces. To prevent environmental allergies, use high-efficiency particulate air (HEPA) filters in your home, keep windows closed during high pollen seasons, wash bedding weekly in hot water to eliminate dust mites, and shower after outdoor activities to remove pollen from your skin and hair. Remove shoes at the door to avoid tracking allergens inside, keep pets out of bedrooms if you have pet allergies, and use allergen-proof covers on mattresses and pillows. Always carry emergency medications and wear medical alert identification if you have severe allergies.
What natural remedies help with allergic reactions?
Several natural approaches can help manage mild allergic reaction symptoms, though they should not replace medical treatment for severe allergies. Quercetin, a natural antihistamine found in onions, apples, and berries, may help stabilize mast cells and reduce histamine release when taken as a supplement. Local honey consumed daily may help your body build tolerance to local pollen allergens over time. Probiotics support immune system balance and may reduce allergic response severity by promoting healthy gut bacteria. Saline nasal rinses using a neti pot can flush allergens from nasal passages and reduce congestion. Omega-3 fatty acids from fish oil have anti-inflammatory properties that may decrease allergic inflammation. Vitamin C acts as a natural antihistamine and can help reduce allergy symptoms. However, always consult your healthcare provider before starting any supplements, especially if you have severe allergies or take medications.
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Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
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Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

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Only HSA & FSA is accepted.

Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.

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If you have any questions, please text us at 754-799-7833 or email [email protected].
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As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

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You can read more about our cancellation policy here.
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If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
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Demo results
IgG4 Antibody to Shrimp 4.8 mcg/mL
Demo results
Normal < 2.0 Elevated ≄ 2.0
4.8 mcg/mL

What this means

Your IgG4 antibody level to shrimp is elevated, suggesting your immune system is producing a response to this food. This may contribute to delayed symptoms like bloating, digestive discomfort, or inflammation that appear hours or days after eating shrimp or shellfish.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

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* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

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IgG4 Food Panel III
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

Sample results

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