Allergic Fungal Sinusitis Blood Test

What is Allergic fungal sinusitis?

Allergic fungal sinusitis is a chronic inflammatory condition of the sinuses caused by an allergic reaction to airborne fungi. It is caused by mold spores including Aspergillus, Alternaria, Curvularia, and other environmental fungi that trigger an excessive immune response in susceptible individuals. The Respiratory Allergy Profile for your region is the most important test for identifying specific fungal triggers causing your symptoms.

RECOMMENDED TEST Respiratory Allergy Profile Region XI: AZ (mountains), CO, ID (mountains), MT, NM, UT, WY
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What causes allergic fungal sinusitis?

Allergic fungal sinusitis is caused by an allergic reaction to environmental mold spores including Aspergillus, Alternaria, Curvularia, Bipolaris, and other fungi commonly found in soil, decaying vegetation, and damp indoor environments. When you inhale these spores, your immune system overreacts, triggering chronic inflammation in the sinus cavities. This inflammatory response causes thick mucus buildup, nasal polyps, and tissue swelling that blocks normal sinus drainage, creating a cycle of persistent symptoms.

What is the best test for allergic fungal sinusitis?

The Respiratory Allergy Profile for your geographic region is the most important test for allergic fungal sinusitis because it identifies the specific molds and fungi triggering your allergic response. This blood test measures IgE antibodies to common environmental molds like Aspergillus, Alternaria, and Cladosporium that are prevalent in your area. Knowing exactly which fungi you are allergic to helps your doctor create a targeted treatment plan including specific environmental avoidance strategies and antifungal therapies. While imaging studies and sinus tissue samples are needed for definitive diagnosis, allergy testing is essential for identifying your specific triggers and preventing symptom recurrence.

When should I get tested for allergic fungal sinusitis?

You should get tested if you have chronic sinus congestion lasting more than 12 weeks that does not respond to standard treatments, especially if you notice thick, discolored nasal discharge or decreased sense of smell. Testing is particularly important if you experience facial pain or pressure that worsens in damp environments or during certain seasons, or if you have a history of asthma or other allergies. Get tested promptly if you have recurrent sinus infections requiring multiple rounds of antibiotics, as this pattern often indicates an underlying fungal allergy rather than bacterial infections.

What are the symptoms of allergic fungal sinusitis?
The main symptoms include chronic nasal congestion, thick mucus discharge that may appear dark or greenish, facial pressure or pain especially around the cheeks and forehead, and a decreased or lost sense of smell. You might also experience headaches, postnasal drip, coughing, fatigue, and difficulty breathing through your nose. Many people notice their symptoms worsen in humid weather, during certain seasons when mold counts are high, or in damp indoor environments like basements.
Who is at risk for allergic fungal sinusitis?
People with existing allergies, asthma, or atopic conditions like eczema have a higher risk of developing allergic fungal sinusitis. Those living in warm, humid climates or areas with high environmental mold exposure face increased risk, as do individuals who work outdoors or in damp indoor environments. Young to middle-aged adults are most commonly affected, and having a family history of allergies increases your susceptibility. Living in mountainous regions of the western United States where specific mold species thrive also elevates your risk.
What happens if allergic fungal sinusitis is left untreated?
Untreated allergic fungal sinusitis leads to progressive sinus damage, including chronic inflammation that can permanently impair your sense of smell and taste. The condition often causes nasal polyps to develop and grow larger over time, potentially blocking sinus drainage completely and creating chronic infections. Severe cases can result in bone erosion in the sinuses and surrounding structures, and may cause the infection to spread beyond the sinuses. Long-term untreated allergic fungal sinusitis significantly impacts quality of life through persistent facial pain, chronic fatigue, and breathing difficulties.
Can allergic fungal sinusitis be diagnosed with a blood test?
Blood tests cannot diagnose allergic fungal sinusitis by themselves, but allergy blood testing plays a crucial supporting role in the diagnostic process. These tests identify which specific molds and fungi you are allergic to by measuring IgE antibodies in your blood. A definitive diagnosis requires a combination of blood allergy testing, CT imaging showing characteristic sinus patterns, and examination of sinus mucus or tissue samples. The blood test results help confirm the allergic component and guide your treatment plan once the diagnosis is established.
How is allergic fungal sinusitis treated?
Treatment typically involves oral and nasal corticosteroids to reduce inflammation, often combined with antifungal medications to address the fungal component. Many patients require endoscopic sinus surgery to remove thick mucus, polyps, and fungal debris that block sinus drainage. After surgery, ongoing treatment includes nasal rinses with saline or medicated solutions, allergy medications, and sometimes immunotherapy for specific mold allergies. Environmental control measures to reduce mold exposure in your home and workplace are essential for preventing recurrence.
How can I prevent allergic fungal sinusitis?
Control indoor humidity levels below 50% using dehumidifiers, especially in basements and bathrooms where mold thrives. Fix water leaks promptly, ensure proper ventilation in damp areas, and clean visible mold with appropriate solutions. Use HEPA air filters in your home and avoid outdoor activities when mold counts are high, particularly during fall and spring. If you know you are allergic to specific molds, take preventive allergy medications during high-exposure seasons and consider wearing a mask when doing yard work or handling compost.
What can I do at home for allergic fungal sinusitis?
Use daily saline nasal rinses to flush out mucus and allergens from your sinuses, which helps reduce inflammation and prevent mucus buildup. Run a HEPA air purifier in your bedroom and main living areas to filter out mold spores. Apply warm compresses to your face several times daily to ease sinus pressure and pain. Stay well-hydrated to help thin mucus secretions, and avoid known triggers like damp environments or areas with visible mold. Keep your living space clean and dry, and wash bedding weekly in hot water to reduce allergen exposure.
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Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?
Absolutely! We totally understand that errors can happen. No worries, we're here to help you.

Just reach out to us via text at 754-799-7833 or shoot us an email at [email protected]. Remember to include your order number and let us know the correct information you’d like to update. Our awesome team will jump right in and make sure everything is sorted out and accurate for you.

There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.

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This policy applies to all insurance companies, including federal health insurance programs like Medicare.

If you have any questions, please text us at 754-799-7833 or email [email protected].
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As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.

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You can read more about our cancellation policy here.
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During the ordering process, you’ll be able to select a specific lab near you, with no strings attached! You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).

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If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
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Demo results
Cat Dander IgE 3.8 kU/L
Demo results
Low Optimal 0.0 - 0.35 High
3.8 kU/L

What this means

Your IgE antibody levels to cat dander are elevated, indicating you're sensitized to cat allergens. This sensitization may be causing symptoms like sneezing, runny nose, itchy eyes, or breathing difficulties when you're around cats or in environments where cats have been present.

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* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

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Respiratory Allergy Profile Region XI: AZ (mountains), CO, ID (mountains), MT, NM, UT, WY
What's included
Fast & easy, results by email & SMS
No need to visit a doctor
Private & confidential
No insurance needed
Results explained
No extra fees paid at the lab

Sample results

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