Sample results
Aging is a natural biological process characterized by progressive physiological changes in cellular function, immune response, and hormonal balance. It is caused by declining levels of key biomarkers including Coenzyme Q10, DHEA hormone, and changes in the CD4:CD8 lymphocyte ratio. The Lymphocyte Subset Panel 4 (CD4:CD8 Ratio Profile) is the most important test for assessing immune system aging and mortality risk.
Aging is caused by progressive cellular damage, oxidative stress, declining hormone production, and gradual deterioration of immune system function. At the cellular level, aging occurs when mitochondria produce less energy, DNA accumulates damage, and telomeres (protective caps on chromosomes) shorten with each cell division. Key hormones like DHEA and growth hormone decline, while chronic low-grade inflammation increases throughout the body. The immune system weakens as the ratio of CD4 helper cells to CD8 suppressor cells decreases, making you more vulnerable to infections and diseases.
The Lymphocyte Subset Panel 4 (CD4:CD8 Ratio Profile) is the most important test for assessing biological aging because it measures immune system health by tracking the ratio of CD4 helper cells to CD8 suppressor cells. A declining CD4:CD8 ratio is strongly associated with increased mortality risk and accelerated aging. Additional essential tests include the Coenzyme Q10(3) test, which measures cellular energy production capacity, and the DHEA test, which evaluates hormone levels that naturally decline with age. Together, these three tests provide a comprehensive picture of how your body is aging at the immune, cellular, and hormonal levels.
You should get tested if you are over 40 and want to establish baseline health markers, experiencing unexplained fatigue or reduced energy levels, noticing decreased muscle mass or increased body fat despite consistent exercise, dealing with declining sexual function or libido, or have a family history of age-related diseases like heart disease or osteoporosis. Testing is also valuable if you are starting an anti-aging regimen and want to monitor its effectiveness, or if you want to optimize your health span and identify areas for intervention before symptoms appear.
What this means
Your CD4:CD8 ratio is below the optimal range, which is common in HIV infection and indicates that your immune system is working harder than usual. This inverted ratio suggests your CD4 helper cells are lower relative to CD8 suppressor cells, which is important information for your doctor to assess disease progression and treatment effectiveness.
Recommended actions
Discuss your current antiretroviral therapy with your doctor to ensure optimal treatment
Focus on a nutrient-rich diet with adequate protein, vitamins, and minerals to support immune function
Prioritize consistent sleep, stress management, and regular gentle exercise as tolerated
Retest in 3-4 months to monitor how your immune system responds to treatment adjustments
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Sample results
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