Understanding Lab Tests for Afibrinogenemia
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Afibrinogenemia is a rare, inherited bleeding disorder characterized by the complete absence or extremely low levels of fibrinogen, a protein essential for blood clotting. This condition requires specialized blood tests for accurate diagnosis, as fibrinogen levels must be measured directly to confirm the disorder.
Top Recommended Test
Fibrinogen Activity
This test uses the Clauss method to measure functional fibrinogen levels in the blood. In afibrinogenemia, this test would show extremely low to undetectable levels of fibrinogen activity, providing direct evidence of the body's inability to produce this essential clotting protein.
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Diagnosing Afibrinogenemia
Since afibrinogenemia is caused by genetic mutations that prevent the production of functional fibrinogen, blood tests that measure fibrinogen levels are the primary diagnostic tools. Patients with this condition will show extremely low to undetectable levels of fibrinogen in their blood, which distinguishes it from other bleeding disorders.
Other Relevant Tests
Fibrinogen Antigen
This test measures the actual amount of fibrinogen protein present in the blood, regardless of its function. Extremely low or undetectable levels of fibrinogen antigen provide confirmatory evidence of afibrinogenemia, supporting the diagnosis of this rare inherited bleeding disorder.
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Understanding Your Results
Normal fibrinogen levels typically range from 200-400 mg/dL. In afibrinogenemia, both fibrinogen activity and antigen levels will be extremely low or completely absent. These results, combined with clinical symptoms such as excessive bleeding, help healthcare providers confirm the diagnosis and develop appropriate treatment plans.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment of bleeding disorders.
