Question 1

What is Adrenocorticotropic Hormone Deficiency?

Accepted Answer

Adrenocorticotropic hormone (ACTH) deficiency is an endocrine disorder where the pituitary gland fails to produce sufficient ACTH. It is caused by pituitary gland dysfunction that prevents adequate stimulation of the adrenal glands to produce cortisol. The Adrenocorticotropic Hormone (ACTH) test is the most important test for diagnosis because it directly measures ACTH levels in the blood.

Question 2

What causes ACTH deficiency?

Accepted Answer

ACTH deficiency is caused by pituitary gland dysfunction that prevents the gland from producing adequate amounts of adrenocorticotropic hormone. This can result from pituitary tumors, traumatic brain injury, radiation therapy to the brain, surgical removal of pituitary tissue, infections affecting the pituitary gland, or autoimmune conditions. Without sufficient ACTH production, the adrenal glands receive inadequate signals to produce cortisol, leading to symptoms like chronic fatigue, muscle weakness, weight loss, and dangerously low blood pressure.

Question 3

What is the best test for ACTH deficiency?

Accepted Answer

The Adrenocorticotropic Hormone (ACTH) test is the most important test for ACTH deficiency because it directly measures the level of ACTH circulating in your bloodstream. This test detects whether your pituitary gland is producing enough ACTH to stimulate cortisol production by the adrenal glands. Low ACTH levels confirm the diagnosis and help distinguish pituitary-related deficiency from primary adrenal insufficiency. Your healthcare provider may also order a cortisol test alongside the ACTH test to see how low ACTH levels are affecting your adrenal function and cortisol production.

Question 4

When should I get tested for ACTH deficiency?

Accepted Answer

You should get tested if you experience persistent fatigue that does not improve with rest, unexplained muscle weakness, dizziness or fainting episodes related to low blood pressure, unexpected weight loss without trying, or darkening of the skin in certain areas. Testing is especially important if you have a history of pituitary problems, brain injury, brain surgery, or radiation therapy to the head, as these conditions significantly increase your risk. Early diagnosis through blood testing helps prevent serious complications like adrenal crisis and guides appropriate hormone replacement therapy.

Question 5

What are the symptoms of ACTH deficiency?

Accepted Answer

The symptoms of ACTH deficiency include severe and persistent fatigue, muscle weakness, weight loss, loss of appetite, nausea and vomiting, low blood pressure that worsens when standing, and dizziness or fainting. You might also experience headaches, confusion, depression, irritability, and in some cases, low blood sugar levels. Women may notice changes in menstrual periods. These symptoms develop because insufficient ACTH leads to low cortisol production, affecting metabolism, stress response, blood pressure regulation, and energy levels throughout your body.

Question 6

Who is at risk for ACTH deficiency?

Accepted Answer

People at higher risk for ACTH deficiency include those with a history of pituitary tumors or pituitary surgery, individuals who have received radiation therapy to the brain or pituitary area, and those with traumatic brain injuries. People with autoimmune conditions affecting the pituitary gland, those taking long-term corticosteroid medications that can suppress pituitary function, and individuals with genetic conditions affecting pituitary development are also at increased risk. Additionally, people with other pituitary hormone deficiencies or hypothalamic disorders face higher risk of developing ACTH deficiency.

Question 7

What happens if ACTH deficiency is left untreated?

Accepted Answer

Untreated ACTH deficiency can lead to life-threatening complications, most seriously an adrenal crisis characterized by severe low blood pressure, shock, loss of consciousness, and potentially death. Chronic untreated deficiency causes progressive weakness, severe fatigue that interferes with daily activities, dangerous drops in blood sugar, persistent low blood pressure, increased susceptibility to infections, and poor stress response. Even minor illnesses or physical stress can trigger a medical emergency. Long-term complications include severe dehydration, electrolyte imbalances, cardiovascular problems, and significantly reduced quality of life. Early diagnosis and treatment with hormone replacement therapy prevents these serious outcomes.

Question 8

Can ACTH deficiency be diagnosed with a blood test?

Accepted Answer

Yes, ACTH deficiency is diagnosed with a blood test that measures the level of adrenocorticotropic hormone in your bloodstream. The ACTH blood test is typically performed in the morning when ACTH levels are naturally highest. Your healthcare provider may also order simultaneous cortisol testing to evaluate how the deficiency is affecting adrenal function. In some cases, stimulation tests may be performed where ACTH or other hormones are administered, followed by blood testing to see how your body responds. These blood tests provide definitive evidence of ACTH deficiency and help distinguish it from other conditions causing similar symptoms.

Question 9

How is ACTH deficiency treated?

Accepted Answer

ACTH deficiency is treated with hormone replacement therapy, primarily using hydrocortisone or other corticosteroid medications to replace the missing cortisol that your adrenal glands cannot produce without adequate ACTH stimulation. Your healthcare provider will prescribe a specific dosage tailored to your individual needs, typically taken in divided doses throughout the day to mimic natural cortisol rhythms. During times of illness, injury, or stress, you may need to temporarily increase your medication dose. Regular blood tests monitor your hormone levels and treatment effectiveness. Treatment is usually lifelong and requires close medical supervision to adjust dosages as needed and prevent complications.

Question 10

How can I prevent ACTH deficiency?

Accepted Answer

While ACTH deficiency caused by genetic conditions, tumors, or injuries cannot always be prevented, you can reduce some risks by protecting your head from traumatic injuries through wearing seatbelts and appropriate safety gear during activities. If you require long-term corticosteroid therapy, work closely with your healthcare provider to use the lowest effective dose and gradually taper off when possible to minimize pituitary suppression. Regular monitoring is essential if you have pituitary conditions or undergo brain radiation therapy. Early detection through blood testing allows for prompt treatment before serious complications develop.

Question 11

What can I do at home for ACTH deficiency?

Accepted Answer

At home with ACTH deficiency, take your prescribed hormone replacement medications exactly as directed, never missing doses or stopping without medical guidance. Wear a medical alert bracelet indicating your condition so emergency responders know you require corticosteroid therapy. Keep extra medication on hand and carry an emergency injection kit if prescribed. Maintain regular meal times to help stabilize blood sugar, stay well-hydrated, and get adequate rest. Monitor yourself for signs of worsening symptoms or illness, which may require medication dose adjustments. Avoid excessive stress when possible, and communicate with your healthcare provider about any changes in your condition or medication side effects.

Question 12

How’s this work?

Accepted Answer

Getting your blood test with us is easy, private & backed by the power of science.Long story short:
            
                In the test options, use the filters or search box to narrow your choices and find the test you want.
                If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
                Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
                If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
                When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
                Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
                You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!
                If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

Question 13

How do I know which test to get?

Accepted Answer

In the test options, find the test you want.
            If you’re not sure which test to get, we can lend a hand in finding the right option.
            Just text or call us at 754-799-7833, email us at support@privatemdlabs.com, and we'll gladly help you. We've got your back and reply quickly.

Question 14

When will my lab results be available?

Accepted Answer

Most test results will be available within 1–3 business days. Once they're ready, we'll send an email and text message to let you know.
            After your blood draw, just hang tight and don't worry – we'll keep you updated and in the loop!
            If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com, and we'll gladly help you.

Question 15

Is it possible to make changes to my lab order if I made a mistake with the name, date of birth, or any other details?

Accepted Answer

Absolutely! We totally understand that errors can happen. No worries, we're here to help you.
            Just reach out to us via text at 754-799-7833 or shoot us an email at
            support@privatemdlabs.com. Remember to include your order number and let us know the correct information you’d like to update.
            Our awesome team will jump right in and make sure everything is sorted out and accurate for you.
            There are no changes necessary if your address is wrong on the requisition though. We don’t mail anything out.
            Our lab requires an address to be listed to generate an order.

Question 16

Do you accept health insurance?

Accepted Answer

Only HSA & FSA is accepted.
            Our services are strictly self-pay and cannot be submitted to your health insurance provider except for Health Savings Accounts or Flexible Savings Accounts.
            This policy applies to all insurance companies, including federal health insurance programs like Medicare.
            If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com.

Question 17

Can I cancel my order?

Accepted Answer

Yes.
            We get it – sometimes your needs change.
            As long as your samples haven’t been collected yet, we’re happy to help you cancel your order.
            If you have any further questions, please text us at 754-799-7833 or email support@privatemdlabs.com.
            You can read more about our cancellation policy here.

Question 18

How can I find a lab location near me?

Accepted Answer

During the ordering process, you’ll be able to select a specific lab near you, with no strings attached!
            You can switch it up later easily and visit any of our authorized locations as long as it’s the same lab company you selected your test for (Quest Diagnostics or Labcorp).
            Before you proceed with your order, feel free to browse through all our lab locations here. This will give you the peace of mind of knowing that there's a lab nearby your home, office or your favorite gym.
            If you have any questions, please text us at 754-799-7833 or email support@privatemdlabs.com and we'll gladly help you.

ACTH Deficiency Blood Test

What is Adrenocorticotropic Hormone Deficiency?

What causes ACTH deficiency?

What is the best test for ACTH deficiency?

When should I get tested for ACTH deficiency?

References

Here’s why 1,000,000+ customers chose us for affordable hassle-free private blood testing.

Us vs. Them

1,000,000+ blood tests later, here's what our customers say

Ask Me Anything