Understanding Lab Tests for Adrenocorticotropic Hormone Deficiency
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Adrenocorticotropic hormone (ACTH) deficiency is a serious endocrine disorder where the pituitary gland fails to produce sufficient ACTH. This hormone is essential for stimulating the adrenal glands to produce cortisol, a vital hormone for stress response and metabolism. Without adequate ACTH, cortisol levels drop, leading to various symptoms including fatigue, muscle weakness, and low blood pressure.
Recommended Test
Adrenocorticotropic Hormone (ACTH)
This test directly measures ACTH levels in the blood, which is essential for diagnosing ACTH deficiency. Low ACTH levels indicate that the pituitary gland is not producing enough of this hormone, which leads to decreased cortisol production by the adrenal glands and the characteristic symptoms of fatigue, low blood pressure, and muscle weakness.
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Diagnosing ACTH Deficiency
Since the symptoms of ACTH deficiency can mimic other conditions, a definitive diagnosis requires specific blood testing to measure hormone levels. The ACTH test is the primary diagnostic tool that directly measures the amount of this crucial hormone in the bloodstream, helping healthcare providers confirm the diagnosis and determine appropriate treatment.
Understanding Test Results
Low ACTH levels in the blood typically confirm the diagnosis of ACTH deficiency. Your healthcare provider will interpret the results in conjunction with your symptoms and may recommend additional testing to determine the underlying cause of the deficiency, such as pituitary gland dysfunction.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.
