Understanding Lab Tests for Adrenocortical Insufficiency
Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025
Adrenocortical insufficiency, also known as Addison's disease in its primary form, is a serious condition where the adrenal glands fail to produce adequate amounts of essential hormones, particularly cortisol and aldosterone. Blood testing is crucial for diagnosing this condition and monitoring hormone levels.
Recommended Test
Aldosterone/Plasma Renin Activity Ratio, LC/MS/MS
This specialized test measures both aldosterone levels and plasma renin activity using highly accurate LC/MS/MS technology. In adrenocortical insufficiency, aldosterone levels are typically low while renin activity may be elevated, creating an abnormal ratio that helps confirm the diagnosis of insufficient adrenal hormone production.
2907 reviews
Why Blood Testing is Essential for Diagnosis
The symptoms of adrenocortical insufficiency, such as fatigue, weakness, weight loss, and low blood pressure, can be vague and overlap with many other conditions. Definitive diagnosis requires blood tests that measure specific adrenal hormones to confirm insufficient production by the adrenal glands.
Understanding Your Test Results
Low aldosterone levels combined with elevated renin activity can indicate primary adrenocortical insufficiency, where the adrenal glands themselves are damaged. The ratio between these hormones provides important diagnostic information that helps healthcare providers determine the appropriate treatment approach, typically involving hormone replacement therapy.
Important Considerations
The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment. Adrenocortical insufficiency is a serious condition that requires prompt medical attention and ongoing management.
