What causes adrenal tumors?

Adrenal tumors are caused by abnormal cell growth in the adrenal glands, which sit on top of your kidneys. Most adrenal tumors develop spontaneously without a clear cause, though some may be linked to genetic conditions like Multiple Endocrine Neoplasia or Li-Fraumeni syndrome. The tumors can be either functioning (hormone-producing) or non-functioning, with functioning tumors causing overproduction of hormones like cortisol, aldosterone, estrone, or adrenaline that disrupt your body's normal balance.

What is the best test for adrenal tumors?

The Estrone LC/MS/MS test is the most important blood test for adrenal tumors because it precisely measures estrone hormone levels that adrenal tumors often overproduce. This advanced test uses liquid chromatography-tandem mass spectrometry for accurate detection of hormone imbalances. While imaging studies like CT or MRI scans are needed to visualize the actual tumor, blood hormone testing is essential for determining if the tumor is functionally active and how it affects your body. Monitoring estrone levels also helps doctors track treatment effectiveness and tumor activity over time.

When should I get tested for adrenal tumors?

You should get tested if you experience unexplained weight gain, persistent high blood pressure that is difficult to control, sudden changes in blood sugar levels, or unusual fatigue and weakness. Other warning signs include rapid heartbeat, excessive sweating, anxiety attacks, or developing purple stretch marks on your abdomen. If an adrenal mass is discovered on imaging done for another reason, hormone testing is essential to determine if the tumor is producing excess hormones that require treatment.

What are the symptoms of adrenal tumors?

Adrenal tumor symptoms depend on whether the tumor produces hormones and which hormones are affected. Common symptoms include unexplained weight gain or loss, high blood pressure, rapid heartbeat, excessive sweating, anxiety, muscle weakness, and fatigue. You might also notice purple stretch marks, easy bruising, increased thirst and urination, mood changes, or irregular menstrual periods in women. Some adrenal tumors cause no symptoms at all and are discovered accidentally during imaging tests for other conditions.

Who is at risk for adrenal tumors?

Anyone can develop adrenal tumors, but certain factors increase your risk. People with genetic syndromes like Multiple Endocrine Neoplasia (MEN1 or MEN2), Von Hippel-Lindau disease, or Li-Fraumeni syndrome have higher risk. Family history of adrenal or endocrine tumors also increases susceptibility. Adrenal tumors are most commonly discovered in adults between ages 40-60, though they can occur at any age. Women are slightly more likely than men to develop certain types of adrenal tumors.

What happens if adrenal tumors are left untreated?

Untreated adrenal tumors that produce excess hormones can lead to serious health complications. Chronic hormone overproduction can cause uncontrolled high blood pressure leading to heart disease and stroke, diabetes from elevated blood sugar, osteoporosis from excess cortisol, and significant weight changes. You may develop severe electrolyte imbalances that affect heart rhythm and muscle function. While most adrenal tumors are benign, some can be cancerous and may spread to other organs if not treated promptly, making early detection and monitoring crucial for the best outcomes.

Can adrenal tumors be diagnosed with a blood test?

Blood tests cannot diagnose the physical presence of an adrenal tumor, but they are essential for detecting hormone overproduction caused by functioning tumors. Tests like Estrone LC/MS/MS measure specific hormone levels to determine if a tumor is actively producing excess hormones. Imaging studies such as CT scans or MRI are required to visualize and confirm the tumor itself. The combination of imaging to locate the tumor and blood tests to assess hormonal function provides the complete diagnostic picture needed for proper treatment planning.

How are adrenal tumors treated?

Treatment for adrenal tumors depends on whether they produce hormones, their size, and whether they are cancerous. Small, non-functioning tumors may only require regular monitoring with imaging and blood tests. Functioning tumors that overproduce hormones typically need surgical removal to prevent complications. Surgery involves removing the affected adrenal gland (adrenalectomy), which can often be done laparoscopically with smaller incisions. If the tumor is cancerous, additional treatments like chemotherapy, radiation, or targeted medications may be necessary after surgery.

How can I prevent adrenal tumors?

Most adrenal tumors cannot be prevented because they develop spontaneously without known preventable causes. However, if you have a genetic syndrome associated with adrenal tumors, regular screening with your doctor can detect tumors early when they are most treatable. Maintaining overall health through regular exercise, a balanced diet, stress management, and avoiding smoking may support your endocrine system function. If you have a family history of adrenal or endocrine tumors, discuss genetic counseling and appropriate screening schedules with your healthcare provider.

What can I do at home for adrenal tumors?

While adrenal tumors require medical treatment, you can support your overall health at home by managing symptoms caused by hormone imbalances. Maintain a balanced diet low in sodium if you have high blood pressure, and monitor your blood sugar if affected. Practice stress-reduction techniques like meditation, yoga, or deep breathing exercises to help manage anxiety and support adrenal function. Get adequate sleep, stay physically active within your ability, and keep all medical appointments for monitoring. Track your symptoms in a journal to help your doctor assess how the tumor affects you over time.

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Adrenal Tumor Blood Test | Private MD Labs

Adrenal Tumor Blood Test

What is Adrenal tumors?

Adrenal tumors are growths that develop in the adrenal glands located on top of the kidneys. They are caused by abnormal cell growth that can lead to overproduction of hormones including cortisol, aldosterone, and estrone. The Estrone LC/MS/MS blood test is the most important test for detecting hormone imbalances caused by adrenal tumors.

Written by Private MD Labs Medical Team

Last updated: December 30, 2025

Getting your blood test with us is easy, private & backed by the power of science.

Long story short:

In the test options, use the filters or search box to narrow your choices and find the test you want.
If you need a hand navigating through options, text our super friendly support team at 754-799-7833, and we'll provide tailored suggestions to help you find the ideal test.
Once your order is placed, we’ll create your doctor’s lab order remotely, without any need for you to make a trip to a doctor in person or to talk to the doctor. Expect to receive your doctor’s lab order right in your inbox. It will also be in your patient portal if you need to find it later. We’ll also include instructions regarding fasting and other requirements for your test. Your patient portal will be auto-created hassle-free during checkout.
If this is your first time ordering, you'll be prompted to create a password for instant login access to your patient portal. It's a quick way to conveniently access your orders and results whenever you want.
When you’re ready, visit one of our 4,000 locations. Just bring your ID – no printing or faxing of your lab order is needed, as your order and details will already be in the lab system.
Note that most lab locations don’t accept walk-ins, so it’s best to book an appointment in advance. Don’t worry – we’ll provide detailed instructions along the way.
You’ll get your results via email & SMS and dive into understanding your body better. Yup, that easy!

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