Adrenal Tumor Blood Test

What is Adrenal Tumor or Cancer?

Adrenal tumors are abnormal growths in the adrenal glands that produce essential hormones like cortisol, aldosterone, and DHEA-S. They are caused by uncontrolled cell growth in the adrenal cortex or medulla, leading to hormone overproduction or disruption. The Adrenocorticotropic Hormone (ACTH) test is the most important test for diagnosis because it detects hormone abnormalities that indicate functioning adrenal tumors.

RECOMMENDED TEST Adrenocorticotropic Hormone (ACTH)
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What causes adrenal tumors?

Adrenal tumors are caused by uncontrolled cell growth in the adrenal glands, which sit on top of your kidneys and produce hormones like cortisol, aldosterone, and DHEA-S. Most adrenal tumors are benign (non-cancerous), but some can be malignant adrenal cancers. The exact cause is often unknown, but genetic mutations, inherited conditions like Li-Fraumeni syndrome or Multiple Endocrine Neoplasia, and random cellular changes can trigger tumor development. Many adrenal tumors are functioning tumors, meaning they overproduce hormones and cause noticeable symptoms.

What is the best test for adrenal tumors?

The Adrenocorticotropic Hormone (ACTH) test is the most important blood test for adrenal tumors because it detects hormone abnormalities that indicate whether a tumor is producing excess hormones. Elevated ACTH levels can signal certain types of adrenal tumors or cancers that disrupt normal hormone regulation. The DHEA-S Sulfate test is also essential because adrenal tumors often overproduce DHEA-S, and elevated levels can confirm the presence of a functioning adrenal tumor. These blood tests work alongside imaging studies like CT or MRI scans to provide a complete diagnostic picture and help your healthcare provider determine the best course of action.

When should I get tested for adrenal tumors?

You should get tested if you experience symptoms of hormone overproduction such as unexplained weight gain, high blood pressure that is difficult to control, muscle weakness, or unusual fat deposits around your face and neck. You should also consider testing if you notice excessive hair growth, irregular periods, or mood changes like anxiety and depression. Anyone with a family history of adrenal disorders or genetic conditions linked to tumors should get screened regularly. If an imaging scan incidentally discovers an adrenal mass, hormone blood tests are essential to determine if the tumor is functioning and requires treatment.

What are the symptoms of adrenal tumors?
Adrenal tumor symptoms depend on which hormones are overproduced. Cortisol-producing tumors cause Cushing syndrome with weight gain in the face and upper body, purple stretch marks, high blood pressure, diabetes, and easy bruising. Aldosterone-producing tumors lead to low potassium, muscle cramps, excessive thirst, and frequent urination. DHEA-S or androgen-producing tumors cause excessive hair growth, acne, irregular periods in women, and early puberty in children. Some adrenal tumors produce no symptoms and are discovered incidentally during imaging for other conditions.
Who is at risk for adrenal tumors?
Anyone can develop adrenal tumors, but certain factors increase risk. People with genetic syndromes like Li-Fraumeni syndrome, Multiple Endocrine Neoplasia type 2, or familial adenomatous polyposis have higher risk. Adrenal cancer is more common in children under 5 and adults in their 40s and 50s. People with a family history of adrenal disorders or other endocrine tumors should monitor their adrenal health closely. Most adrenal tumors are discovered incidentally in adults over 40 during imaging scans for unrelated conditions.
What happens if adrenal tumors are left untreated?
Untreated functioning adrenal tumors continue to overproduce hormones, leading to serious complications. Excess cortisol causes uncontrolled diabetes, severe osteoporosis, increased infection risk, and heart problems. High aldosterone leads to dangerous potassium depletion, irregular heartbeat, and stroke. Adrenal cancers can grow larger, spread to other organs like the liver and lungs, and become life-threatening. Even benign tumors that produce excess hormones can significantly reduce quality of life and cause permanent damage to bones, muscles, and the cardiovascular system if not addressed promptly.
Can adrenal tumors be diagnosed with a blood test?
Blood tests cannot definitively diagnose adrenal tumors, but they are essential for detecting hormone abnormalities that indicate a functioning tumor. The ACTH test and DHEA-S test measure hormone levels that become elevated when adrenal tumors overproduce hormones. Your doctor will also order imaging studies like CT scans or MRI to visualize the tumor itself. Blood tests help determine if a tumor found on imaging is functioning and guide treatment decisions. Additional tests like cortisol levels, aldosterone, metanephrines, and potassium may be ordered based on your symptoms to identify which hormones are affected.
How are adrenal tumors treated?
Treatment depends on tumor type, size, and whether it produces hormones. Benign, non-functioning tumors smaller than 4 cm are often monitored with regular imaging and blood tests. Functioning tumors that overproduce hormones typically require surgical removal through adrenalectomy. Adrenal cancer is treated with surgery to remove the tumor and affected adrenal gland, often followed by chemotherapy with mitotane and radiation therapy if the cancer has spread. Medications can help control hormone overproduction before surgery. Your endocrinologist and surgeon will create a personalized treatment plan based on your specific tumor characteristics.
How can I prevent adrenal tumors?
Most adrenal tumors cannot be prevented because their cause is often unknown or related to genetic factors beyond your control. If you have a family history of genetic syndromes associated with adrenal tumors, genetic counseling and regular screening can help detect tumors early when they are most treatable. Maintaining overall health through balanced nutrition, regular exercise, stress management, and avoiding smoking may support adrenal gland health. Regular check-ups with your doctor can help identify hormone imbalances or symptoms that warrant further investigation before complications develop.
What can I do at home for adrenal tumors?
While adrenal tumors require medical treatment, you can support your overall health at home by managing symptoms and supporting your body during treatment. Eat a balanced diet low in sodium if you have high blood pressure, and ensure adequate calcium and vitamin D intake to protect bone health if cortisol levels are high. Practice stress-reduction techniques like meditation, yoga, or deep breathing to help regulate your nervous system. Get adequate sleep and gentle exercise as tolerated. Keep detailed records of your symptoms and hormone levels to share with your healthcare provider, and take all prescribed medications exactly as directed.
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If you have any questions, please text us at 754-799-7833 or email [email protected] and we'll gladly help you.
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ACTH (Adrenocorticotropic Hormone) 62 pg/mL
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62 pg/mL

What this means

Your ACTH levels are elevated above the optimal range, which may indicate your pituitary gland is working harder to stimulate your adrenal glands. This could suggest your adrenal glands aren't producing enough cortisol, potentially contributing to fatigue, low blood pressure, or difficulty handling stress.

* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

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* Regular blood test results (e.g., CBC) typically start arriving the next business day after sample collection. More complex tests, such as hormone panels, may take up to 10–15 business days due to their complexity.

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Adrenocorticotropic Hormone (ACTH)
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