Understanding Lab Tests for Adrenal Carcinoma

Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025

Adrenal carcinoma is a rare and aggressive cancer that develops in the adrenal glands, which are located above each kidney. While the definitive diagnosis of adrenal carcinoma typically requires imaging studies and tissue biopsy, blood testing plays a fundamental role in detecting hormone overproduction, which is a key characteristic of many adrenal tumors.

Top Recommended Test

Cortisol, Total

This test measures the total amount of cortisol in the blood. Adrenal carcinomas are rare, aggressive cancers that can overproduce cortisol, leading to dangerously high levels in the body. Elevated cortisol can indicate hormone-producing adrenal tumors and help assess the severity of hormonal dysfunction.

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Why Blood Testing is Important for Adrenal Carcinoma

Many adrenal carcinomas are functioning tumors, meaning they produce excess amounts of hormones such as cortisol and aldosterone. Blood tests are essential for detecting these elevated hormone levels, which can help healthcare providers assess adrenal function, monitor disease progression, and evaluate treatment effectiveness. These hormonal imbalances can cause serious health complications if left undetected.

Other Relevant Tests

Aldosterone/Plasma Renin Activity Ratio, LC/MS/MS

This highly sensitive test uses advanced LC/MS/MS technology to detect abnormal levels of aldosterone and assess the ratio with renin activity. Since adrenal carcinoma is a rare and aggressive cancer of the adrenal glands, this precise testing method can identify elevated aldosterone levels that may be associated with hormone-producing adrenal tumors.

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Understanding Hormone Overproduction

When adrenal carcinomas produce excess hormones, they can cause various symptoms and health complications. Elevated cortisol may lead to Cushing's syndrome, while excess aldosterone can cause high blood pressure and electrolyte imbalances. Regular monitoring of these hormone levels is crucial for managing the condition and assessing treatment response.

Important Considerations

The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.

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