Understanding Lab Tests for Acute CMV Infection

Written by Private MD Labs Medical Writing Team • Last Updated: September 8, 2025

Cytomegalovirus (CMV) is a common virus that can cause acute infection, particularly in immunocompromised individuals, pregnant women, and newborns. While many CMV infections are asymptomatic, acute infections can cause significant symptoms and complications, making accurate diagnosis essential for proper treatment and management.

Recommended Test

Cytomegalovirus (CMV) Antibodies, IgM, Quantitative

This test detects IgM antibodies specific to CMV, which are produced by the immune system during acute infection. The presence of CMV IgM antibodies typically indicates a recent or current infection, as these antibodies can be detected within 1-2 weeks after infection begins. This quantitative test provides precise measurement levels to help confirm acute CMV infection.

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Diagnosing Acute CMV Infection

Since CMV infection symptoms can mimic other viral illnesses like mononucleosis or flu, specific blood tests are necessary to confirm an acute infection. The immune system produces specific antibodies in response to CMV infection, and detecting these antibodies helps distinguish between recent and past infections.

Understanding Your Results

IgM antibodies are the first antibodies produced when the immune system encounters CMV for the first time or during reactivation. Positive IgM results suggest acute or recent infection, while negative results typically indicate no current infection. Your healthcare provider will interpret these results along with your symptoms and medical history to determine the most appropriate treatment approach.

Important Considerations

The information here is for educational purposes only and is not a substitute for professional medical advice. Always consult with a healthcare provider for diagnosis and treatment.

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