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Absence of immunity to chickenpox means you lack protective antibodies against the varicella-zoster virus (VZV). This occurs when you have never been infected with chickenpox naturally and have not received the varicella vaccine, or when vaccination did not produce adequate immune response. The Varicella-Zoster Virus Antibodies IgG test is the most important test for determining chickenpox immunity status.
Absence of immunity to chickenpox is caused by never having been exposed to the varicella-zoster virus through natural infection and not receiving the chickenpox vaccine. Some people who were vaccinated may also lack immunity if their immune system did not produce enough protective antibodies in response to the vaccine. Without exposure to the virus or successful vaccination, your body never develops the IgG antibodies needed to fight off chickenpox infection, leaving you vulnerable to the disease.
The Varicella-Zoster Virus Antibodies IgG test is the most important test for determining chickenpox immunity because it directly measures the protective IgG antibodies your body produces after exposure to the varicella-zoster virus or vaccination. This blood test shows whether you have adequate antibody levels to protect against infection. Low or undetectable IgG levels indicate you lack immunity and may need vaccination, while normal or elevated levels confirm you are protected. This single test provides definitive evidence of your immunity status and helps healthcare providers make informed decisions about whether you need the chickenpox vaccine.
You should get tested if you cannot remember having chickenpox as a child, if you work in healthcare or education where exposure risk is high, if you are planning pregnancy or could become pregnant, or if you have a weakened immune system. Testing is especially important before starting immunosuppressive medications or chemotherapy, as chickenpox can be severe in immunocompromised individuals. Adults who grew up in tropical countries where chickenpox occurs less frequently should also consider testing to confirm their immunity status.
What this means
Your test shows positive IgG antibodies to varicella-zoster virus, meaning you have immunity from a previous chickenpox infection. You're protected against getting chickenpox again, though the virus remains dormant in your body and could reactivate as shingles later in life, especially after age 50 or if your immune system weakens.
Recommended actions
Discuss the shingles vaccine with your doctor if you're over 50 to reduce reactivation risk
Maintain a healthy immune system through balanced nutrition and regular exercise
Be aware of early shingles symptoms like tingling or pain along one side of your body
Keep this immunity documentation for employment, healthcare, or travel requirements
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