What is autosomal dominant polycystic kidney disease?
Autosomal dominant polycystic kidney disease (ADPKD) is a genetic disorder that causes multiple fluid-filled cysts to form in the kidneys.
How is autosomal dominant polycystic kidney disease inherited?
Autosomal dominant polycystic kidney disease is inherited in an autosomal dominant pattern, which means that one copy of the mutated gene from one parent is enough to cause the disease.
What are the symptoms of autosomal dominant polycystic kidney disease?
Symptoms of autosomal dominant polycystic kidney disease may include abdominal or back pain, high blood pressure, blood in the urine, frequent UTIs, kidney stones, and kidney failure.
What is the difference between autosomal dominant polycystic kidney disease and autosomal recessive polycystic kidney disease?
Autosomal dominant polycystic kidney disease is a genetic disorder caused by a mutation in the PKD1 or PKD2 gene, while autosomal recessive polycystic kidney disease is caused by a mutation in the PKHD1 gene. Autosomal recessive polycystic kidney disease is less common and tends to cause more severe kidney problems earlier in life.
What is the treatment for autosomal dominant polycystic kidney disease?
Treatment for autosomal dominant polycystic kidney disease may include medications for blood pressure control, pain relief, and management of complications such as UTIs and kidney stones. In some cases, surgery or dialysis may be necessary for kidney failure.
What is the life expectancy for someone with autosomal dominant polycystic kidney disease?
The life expectancy for someone with autosomal dominant polycystic kidney disease varies depending on the severity of their symptoms and the development of complications such as kidney failure. Some patients may live a relatively normal lifespan, while others may experience problems earlier in life that reduce their life expectancy.
What is the prognosis for autosomal dominant polycystic kidney disease?
The prognosis for autosomal dominant polycystic kidney disease depends on the individual patient and the progression of the disease. Some patients may experience few symptoms throughout their life, while others may develop complications such as kidney failure or cysts in other organs.
What is the ICD-10 code for autosomal dominant polycystic kidney disease?
The ICD-10 code for autosomal dominant polycystic kidney disease is Q61.2.
What is an ultrasound used for in the diagnosis of autosomal dominant polycystic kidney disease?
An ultrasound can be used to visualize the cysts in the kidneys and determine their size and number. It can also be used to monitor the progression of the disease over time.
Is autosomal dominant polycystic kidney disease more common than autosomal recessive polycystic kidney disease?
Yes, autosomal dominant polycystic kidney disease is more common than autosomal recessive polycystic kidney disease.
Where can I find more information about autosomal dominant polycystic kidney disease?
You can find more information about autosomal dominant polycystic kidney disease from organizations such as the PKD Foundation and the National Kidney Foundation.
How is autosomal dominant polycystic kidney disease diagnosed?
Autosomal dominant polycystic kidney disease is diagnosed through a combination of medical history, physical exam, and imaging tests such as ultrasound, CT scan, or MRI. Genetic testing can also confirm the presence of the PKD1 or PKD2 gene mutation.
Are there any medications that can slow the progression of autosomal dominant polycystic kidney disease?
There are currently no medications that can cure autosomal dominant polycystic kidney disease, but some medications such as tolvaptan may be used to slow the progression of the disease by reducing cyst growth.
What is the difference between autosomal dominant and autosomal recessive?
Autosomal dominant means that only one copy of the mutated gene is needed to cause the disease, while autosomal recessive means that two copies of the mutated gene are needed to cause the disease.
Is there a cure for autosomal dominant polycystic kidney disease?
There is currently no cure for autosomal dominant polycystic kidney disease, but treatments are available to manage symptoms and prevent complications.
Can autosomal dominant polycystic kidney disease be prevented?
Autosomal dominant polycystic kidney disease is a genetic disorder and cannot be prevented. Genetic counseling can help families understand the risk of passing the disease on to their children.
What are some common complications of autosomal dominant polycystic kidney disease?
Common complications of autosomal dominant polycystic kidney disease may include UTIs, kidney stones, high blood pressure, aneurysms, and kidney failure.
Can autosomal dominant polycystic kidney disease be diagnosed prenatally?
Yes, autosomal dominant polycystic kidney disease can often be diagnosed prenatally through ultrasound or genetic testing.
What is the PKD1 gene?
The PKD1 gene is a gene on chromosome 16 that codes for a protein called polycystin-1. Mutations in the PKD1 gene are responsible for the majority of cases of autosomal dominant polycystic kidney disease.
What is the PKD2 gene?
The PKD2 gene is a gene on chromosome 4 that codes for a protein called polycystin-2. Mutations in the PKD2 gene are responsible for a minority of cases of autosomal dominant polycystic kidney disease.
What is the difference in symptoms between autosomal dominant and autosomal recessive polycystic kidney disease?
The symptoms of autosomal recessive polycystic kidney disease are usually more severe and present at a younger age than those of autosomal dominant polycystic kidney disease. Autosomal recessive polycystic kidney disease may also affect other organs besides the kidneys.
Can autosomal dominant polycystic kidney disease affect other organs besides the kidneys?
Autosomal dominant polycystic kidney disease can sometimes cause cysts in other organs such as the liver, pancreas, and spleen.
What is the genereviews for autosomal dominant polycystic kidney disease?
The genereviews for autosomal dominant polycystic kidney disease are a comprehensive academic review of the literature and current knowledge about the disease.
What is the best way to manage high blood pressure in patients with autosomal dominant polycystic kidney disease?
The best way to manage high blood pressure in patients with autosomal dominant polycystic kidney disease is through lifestyle changes such as exercise, weight loss, and a low-sodium diet, as well as medications such as ACE inhibitors and ARBs.
Can autosomal dominant polycystic kidney disease be asymptomatic?
Yes, some people with autosomal dominant polycystic kidney disease may have few or no symptoms until later in life when the cysts have grown larger and caused damage to the kidneys.
What is the age of onset for autosomal dominant polycystic kidney disease?
The age of onset for autosomal dominant polycystic kidney disease varies, but the disease typically becomes symptomatic in middle age.
Can autosomal dominant polycystic kidney disease be diagnosed in childhood?
Autosomal dominant polycystic kidney disease can sometimes be diagnosed in childhood, but the disease may not become symptomatic until later in life.
What is the difference between a cyst and a tumor in the kidneys?
A cyst is a fluid-filled sac that is often benign, while a tumor is a solid mass that may be benign or malignant.
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