Acromegaly Testing

Acromegaly Screen (Basic)

Biomarkers: 4

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Acromegaly Screen (Basic) (Quest Diagnostics)

Same day lab order delivery

HSA/FSA reimbursable

Description

Acromegaly is a hormonal disorder. It develops when your pituitary gland, located deep in the brain, produces too much growth hormone (GH). Growth hormone affects growth of all tissues of the body, especially bone.

This screen is used to aid in the diagnosis of acromegaly.

Significant deviations from the normal range may require further evaluation by your physician.

Includes

Glucose, Serum
Insulin-Like Growth Factor I (IGF-I, LC/MS)
Thyroid-Stimulating Hormone (TSH)
Thyroxine Free, Direct Dialysis (FT4)

Patient Instructions

Fasting required. Fasting is defined as no consumption of food or beverage other than water for at least 8 hours before testing. Samples should not be collected during or soon after the administration of Heparin.

Estimated turnaround for results is 7 business days. If confirmation testing is required, the estimated time may be extended.

Acromegaly Screen (Basic) (LabCorp)

Same day lab order delivery

HSA/FSA reimbursable

Description

Acromegaly is a hormonal disorder. It develops when your pituitary gland, located deep in the brain, produces too much growth hormone (GH). Growth hormone affects growth of all tissues of the body, especially bone.

This screen is used to aid in the diagnosis of acromegaly. Significant deviations from the normal range may require further evaluation by your physician.

Includes

Glucose, serum;
Insulin-Like Growth Factor I(IGF-1);
Thyroxine Free, Direct (FT4);
Thyroid-Stimulating Hormone (TSH).

Patient Instructions

Patient should fast for 12 hours. Samples should not be collected during or soon after the administration of Heparin. This test may exhibit interference when sample is collected from a person who is consuming a supplement with a high dose of biotin (also termed as vitamin B7 or B8, vitamin H or coenzyme R). It is recommended to stop biotin consumption at least 72 hours prior to the collection of specimen.

Estimated turnaround for results is 3 business days. If confirmation testing is required, the estimated time may be extended.

What is Acromegaly?

Acromegaly is the same disorder caused by IGF-1 excess, yet it occurs after the growth plate cartilage has already been fused during adulthood. It is directly linked to gigantism, which is the abnormally high linear growth caused by excessive action of the insulin-like growth factor 1 (IGF-1), though this particular condition occurs while the ephiphyseal growth plates are still open.
Acromegaly is a serious disease which is often diagnosed later in a patient’s life and is associated with high morbidity and mortality rates, mostly due to the accompanying cardiovascular, cerebrovascular, respiratory disorders and malignancies which are typical in those with the condition.

Who May Need an Acromegaly Screen?

Signs of Acromegaly include those similar to abnormal levels of IGF-1, including large extremities and facial features, as well as masses on the pituitary gland. If you, or someone you know, exhibit these signs, there may be cause to have this test performed. Also, if you have had elevated IGF-1 levels previously, or been treated for IGF-1 abnormalities or Acromegaly before without exhibiting a decrease in the growth hormone, you may want to continue testing until a physician instructs otherwise.

What Should I Expect from My Acromegaly Screen?

Prior to the development of Acromegaly and IGF-1 testing, growth hormone measurement was the only way to diagnose patients with the disease, which is an inferior biochemical method for assessment. Today’s tests are an extremely reliable indicator of the disease in adults who exhibit signs and symptoms of Acromegaly, using a linear dose-response correlation between serum IGF-1 levels and 24-hour integrated growth hormone secretion. Signs of abnormal dynamics of growth hormone secretion during this test typically indicate active Acromegaly in patients.