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Protein C Deficiency ProfileThis test is used for confirmation and characterization of protein C deficiency. Protein C (PC) is a vitamin K-dependent plasma protein that is synthesized by the liver as an inactive precursor. This protein is then further transformed into activated PC by a complex of thrombin and the endothelial factor, thrombomodulin, that is bound to phospholipid membrane in a calcium-dependent manner. aPC regulates the coagulation process by inactivating factors Va and VIIIa. Protein S, another vitamin K-dependent protein, serves as an essential cofactor of aPC for the inactivation of factors Va and VIIIa. In inhibiting these factors, PC serves to limit thrombus extension, and thus acts as a major regulator of the coagulation process. A significant
deviation from the normal range may require further evaluation by your physician.
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