Proinsulin Test
Elevated proinsulin levels have been observed in individuals with impaired glucose tolerance even in the absence of abnormal glucose or C-peptide levels. Elevated proinsulin levels have been found to be a positive risk factor for the development on NIDDM.
High proinsulin concentrations have been associated with benign or malignant β-cell tumors of the pancreas and endocrine pancreatic tumors associated with MEN-1. Most patients with β-cell tumors have increased insulin, C-peptide, and proinsulin concentrations, but occasionally only proinsulin is elevated. Despite its low biological activity, proinsulin may be increased sufficiently to produce hypoglycemia.
Increased proinsulin concentrations may also be detected in patients with chronic renal failure, cirrhosis, or hyperthyroidism. A significant deviation from the normal range may require further evaluation by your physician.
Private MD Lab Services offers the following test for proinsulin:
