Insulin-Like Growth Factor II (IGF-2)

IGF-II is used as an adjunct to IGF-I in the clinical evaluation of growth hormone-related disorders. Insulin-like growth factor II (IGF-II) is an amino acid peptide, which like IGF-I is thought to mediate some of the actions of growth hormone (GH). IGF-II is secreted by the liver and other tissues and is thought to have metabolic actions at or near the sites of synthesis in the liver. It also appears in the peripheral circulation, where it circulates with IGF-binding protein-3 (IGFBP-3). A smaller proportion of IGF-II may circulate in association with other IGF-binding proteins. Plasma levels of IGF-II are dependent upon adequate levels of GH and other factors, including adequate nutrition. The actions of IGF-II are mediated by binding to specific cell surface receptors. IGF-II binds with lower affinity to the IGF-I type receptors and the insulin receptors. Although its specific physiologic role has not been defined, the interplay of IGF-I and IGF-II with the different cell surface receptors and circulating binding proteins modulates tissue growth. IGF-II levels decrease in GH deficiency and in malnutrition. IGF-II levels may also decrease in acromegaly and during exogenous administration of IGF-I.

A significant deviation from the normal range may require further evaluation by your physician.

Private MD Lab Services offers the following test for Insulin-Like Growth Factor II (IGF-2):

Insulin-Like Growth Factor II (IGF-2) $79.49	Add To Cart