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Insulin-Like Growth Factor I (IGF-I) IGF-1, also known as somatomedin-C, is a polypeptide hormone produced by the liver and other tissues in response to growth hormone release by the pituitary gland. IGF-1 effects growth promoting activity and glucose metabolism (insulin-like activity) in most human tissues. It is carried in blood bound to a carrier protein which prolongs its half-life; therefore making serum levels more constant than growth hormone while correlating with with "average" circulating levels of growth hormone. In short, IGF-1 is a surrogate marker of growth hormone levels and activity.
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