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Cryoglobulin, Qualitative, Serum with Quantitative ReflexCryoglobulins may be present in macroglobulinemia of Waldenström, myeloma, chronic lymphocytic leukemia, lupus, chronic active hepatitis, and other viral infections. Cryoglobulins are proteins which precipitate from blood at low temperatures. A precipitate from serum which forms overnight at 4°C and dissolves at 37°C is called a cryoglobulin. Cryoglobulins may be divided into three classes. Type I are monoclonal immunoglobulins and are usually associated with lymphoproliferative disorders. Type II are mixtures of a monoclonal IgM and polyclonal IgG, and are associated with macroglobulinemia and chronic active hepatitis. Type III are mixtures of polyclonal IgM and polyclonal IgG. These are found in a wide variety of disorders.
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