Free Androgen Index (FAI) Serum
The free androgen index can be used to
estimate physiologically active testosterone.
In most men and women, >50% of
total circulating testosterone is bound to sex hormone-binding globulin, SHBG,
and most of the rest is bound to albumin. SHBG-bound testosterone is not readily
available for intracellular complex formation because of SHBG's high binding
affinity for testosterone. Thus, testosterone-bound SHBG is considered to
be biologically inactive. Albumin has a much lower binding affinity for testosterone
but binds a significant portion of the total testosterone because albumin
is present at much higher plasma concentrations than SHBG. The rapid dissociation
of ”weakly bound” testosterone from albumin, together with a relatively long
transit time of albumin through target tissue capillary beds, result in the
availability of essentially all albumin-bound testosterone for steroid-receptor
interaction. The sum of the free- and albumin-bound testosterone is often
referred to as bioavailable testosterone. The concentration of testosterone
in the various free and bound forms is essentially a function of total testosterone
concentration and the relative concentrations of SHBG and albumin. It can
be predicted that increased SHBG will decrease the concentration of both free
and bioavailable testosterone for a given total testosterone concentration.
The free androgen index can be used to estimate physiologically active testosterone.
This index is calculated as the ratio of total testosterone divided by SHBG
(both expressed in the same units) and multiplied by 100 to yield numerical
results comparable in free testosterone concentration.
A significant deviation
from the normal range may require further evaluation by your physician.
Private MD Lab Services
offers the following profile for Free Androgen Index, Serum:
The
Free Adrogen Index contains the following tests:
|
Testosterone, Serum
|
Serum Hormone Binding Globulin (SHBG) |
