Call us: 1.877.283.7882 | Monday–Friday: 8:00 AM–4:30 PM ET

Private MD News

Home | News | Liver Diseases

Genetic variation increases risk of liver cirrhosis

Category: Liver Diseases

Caucasian alcoholics may benefit from liver testing. A new study has found that a genetic variation common to individuals of this ethnicity puts them at an elevated risk of developing alcohol-induced cirrhosis.

Typically, only 10 to 35 percent of alcoholics in the general population develop liver inflammation. Among these individuals, only about 20 percent develop full-blown cirrhosis. However, individuals with the particular genetic variation are at a much higher risk.

After studying the genome of more than 1,000 alcoholics, a team of researchers from Christian-Albrechts-Universität Kiel in Germany found that individuals with a variation on PNPLA3 gene were 25 to 50 percent more likely to develop cirrhosis.

"Our findings show PNPLA3 carriers represent a subpopulation of high-risk individuals susceptible to progression from clinically silent alcoholic liver disease to obvious cirrhosis," said Jochen Hampe, who led the study. "Carriers of this risk allele should be targeted for future pharmaceutical treatments and non-pharmacological interventions."

Given the fact that the variation is most prevalent in Caucasians, these individuals should be particularly careful about over-indulging on alcohol.
 

Related Articles from Private MD:

Share on Facebook

Subscribe to Private MD Health News RSS Feed: Subscribe

News Categories:

Advanced Lipid Treatment I   Allergy Testing   Anemia and RBC disorders   Autoimmune Diseases   Bariatric Lab Testing   Blood and Blood Diseases   Breast   Cancer Detection and Tumor Markers   Celiac Disease Testing   Chlamydia   Coagulation and blood clotting disorders   Colon   Diabetes   DNA, Paternity and Genetic testing   Drug Screening   Environmental Toxin Testing   Female Specific Tests   Gastrointestinal Diseases   General Health   General Wellness   Heart Health and Cholesterol   Herpes   HIV   HIV monitoring/Treatment/Testing/Post Diagnos   Hormones and Metabolism   Infectious Diseases   Infertility Testing-Male   Infertitlity Hormone Testing   Kidney Diseases   Leukemia and WBC disorders   Liver   Liver Diseases   Lyme Disease   Male Specific Tests   Menopause/Peri-Menopausal Diagnosis   Musculoskeletal Diseases   Organ Specific Testing   Ovarian   Prostate   Sexually Transmitted Diseases   Thyroid Diseases   Transgender Hormone Testing-female to male   Transgender Hormone Testing-Male to Female   Vitamin D Deficiency-Diagnosis and Treatment   

Visit the Health News Archive: Click Here

Questions about online blood testing or how to order a lab test? Click here to get started or call us toll-free at 1.877.283.7882. Our professionals are ready to assist you.

Back to top